Conservation of methylation reprogramming in mammalian development: Aberrant reprogramming in cloned embryos

By W. Dean, Fátima Santos, M. Stojkovic, V. Zakhartchenko, Jörn Walter, E. Wolf, Wolf Reik. Proceedings of the National Academy of Sciences of the United States of America, 2001

1,002 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c3dc12197b3946415ffc9965818bb5fc050023d5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Yi Zhang
2. Wolf Reik
3. E. Li
4. A. Bird
5. W. Dean
6. Keith D. Robertson
7. Jörn Walter
8. R. Jaenisch

In Molecular Biology

1. Yi Zhang
2. A. Bird
3. Wolf Reik
4. Hao Wu
5. E. Li
6. Keith D. Robertson
7. W. Dean
8. Dirk Schübeler

Citations in the corpus

• Active DNA Demethylation Mediated by DNA Glycosylases (2009, neutral): “This epigenetic reprogramming involves active DNA demethylation (19).”
• Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals (2003, background): “Faulty epigenetic reprogramming is reflected, for example, in the aberrant methylation of cloned cleavage-stage embryo”
• Chromatin modification and epigenetic reprogramming in mammalian development (2002, background): “Studies of methylation have shown that genome-wide demethylation before implantation is less efficient in cloned bovine embryos, and that de novo methylation occurs at an earlier stage in cloned embryos compared with normal embryo”
• Epigenetic reprogramming in mammals. (2005, background): “De novo methylation results in a methylated ICM, but less methylated TE in mouse (15,17); bovine (26,54); sheep (18).”
• Targets and dynamics of promoter DNA methylation during early mouse development (2010, positive): “In mouse, de novo methylation is initiated around implantation mostly in embryonic cells, whereas extraembryonic cells have lower levels of DNA methylation, as visualized by immunostainin”
• Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse (2003, methodology): “This may be desirable in order to prevent IAP retrotransposition, which could cause mutations.”
• Active DNA demethylation: many roads lead to Rome (2010, background): “Paternal genome demethylation has been observed in many mammalian organisms, including human, mouse, rat, bovine and pi”
• DNA methylation and human disease (2005, background): “Importantly, imprinted DNA methylation patterns are frequently disrupted by in vitro manipulation of embryos in both animals and human”