Survival of Resting Mature B Lymphocytes Depends on BCR Signaling via the Igα/β Heterodimer

By M. Kraus, M. Alimzhanov, Nikolaus Rajewsky, Klaus Rajewsky. 2004

558 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology

View Paper: https://www.semanticscholar.org/paper/c348e004a6e37c3199771a07f491c98543ababf9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. S. Ghosh
2. M. Hayden
3. A. West
4. A. Strasser
5. N. Perkins
6. M. Karin
7. Shao-Cong Sun
8. O. Maier

In Immunology

1. S. Ghosh
2. M. Hayden
3. A. West
4. A. Strasser
5. Ralf Küppers
6. A. Mócsai
7. N. Perkins
8. Shizuo Akira

Citations in the corpus

• PI3 Kinase signals BCR dependent mature B cell survival (2009, unknown): “transitional to mature cells (Kraus et al., 2004), in combination with the B1-8f allele, in which the B1-8 VDJ gene segment, sitting in its physiological position in the IgH locus, is flanked by loxP sites (Lam et al.”
• The SYK tyrosine kinase: a crucial player in diverse biological functions (2010, background): “However, recent studies revealed that the disruption of BCR signalling by inactivation of the ITAM-bearing Igα chain leads to a rapid loss of resting mature B cell”
• Mechanisms of B-cell lymphoma pathogenesis (2005, background): “MALT lymphoma API2–MALT1 (30)135, CD95 (5-80)25,140,141‡ Indirect role of – BCL10–IgH (5)136,137, Helicobactor pylori in MALT1–IgH (15-20)138, gastric MALT FOXP1–IgH (10)139 lymphomas85”
• Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. (2008, unknown): “Since the BCR is known to provide survival signals to B cells (Kraus et al., 2004), we speculate that premature BCR expression from the Ig transgene provided supplemental survival signals that allowed developing B cells to pass the critical pro- to pre-B cell transition without Dicer.”
• The role of BH3-only proteins in the immune system (2005, background): “Developing B cells are also subject to positive selection, but the nature of the selecting ligands is not clear; nevertheless, those B cells that fail positive selection also undergo programmed cell deat”
• NF-κB and the immune response (2006, background): “In large part, these defects appear to be due to a loss of BCR signaling, as demonstrated in an elegant study that demonstrated that deletion of the BCR from mature B cells led to a complete loss of the peripheral B-cell pool (Kraus et al., 2004).”
• Control of lymphocyte development by nuclear factor-κB (2005, unknown): “The BCR is essential for the maintenance of mature B cells, given the complete loss of all mature B cells in which the genes encoding the BCR are conditionally knocked ou”