PI3 Kinase signals BCR dependent mature B cell survival

By L. Srinivasan, Y. Sasaki, D. Calado, Baochun Zhang, J. Paik, R. DePinho, J. Kutok, J. Kearney, K. Otipoby, K. Rajewsky. Cell, 2009

680 citations recorded by the source corpus.

Summary Previous work has shown that mature B cells depend upon survival signals delivered to the cells by their antigen receptor (BCR). To identify the molecular nature of this survival signal, we have developed a genetic approach in which ablation of the BCR is combined with the activation of specific, BCR dependent signaling cascades in mature B cells in vivo. Using this system, we provide evidence that the survival of BCR deficient mature B cells can be rescued by a single signaling pathway downstream of the BCR, namely PI3K signaling, with the FOXO1 transcription factor playing a central role.

Subfields: Immunology, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/27287712608d0c8921fcfca7da7e74b458e02afa

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Citations in the corpus

• The importance of natural IgM: scavenger, protector and regulator (2010, background): “The BCR interacts with endogenous and exogenous ligands to control B cell responses and survival through activation of the phosphoinositide 3-kinase pathwa”