Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury.

By R. C. Lai, F. Arslan, M. Lee, N. Sze, A. Choo, T. Chen, M. Salto‐Tellez, L. Timmers, C. Lee, R. El Oakley and 3 more. Stem Cell Research, 2010

2,105 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c2bb025c5d4d12323679dffb2fb86603b635c2ea

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Citations in the corpus

Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments (2022, methodology): “For example, EVs secreted by mesenchymal stem cells in response to myocardial infarction have been isolated by such size-exclusion methods [148].”
Exosome Theranostics: Biology and Translational Medicine (2018, background): “It is worth emphasizing that stem cells-derived exosomes are a good substitute for therapeutic stem cells as they are not associated with the clinical concern of tumorigenicity [143].”
Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury. (2013, positive): “Serum-free CM collected from MSCs culture was concentrated 50× by tangential flow filtration using a membrane with a 100 kDa MWCO (Sartorius, Goettingen, Germany).”
Biological properties of extracellular vesicles and their physiological functions (2015, background): “In this context, part of this paracrine/endocrine mechanism of MSCs is thought to be mediated by the MSC-derived EVs (493) (Fig.”
Focus on Extracellular Vesicles: Introducing the Next Small Big Thing (2016, background): “, mouse embryonic stem cells EVs enhanced survival and expansion of hematopoietic progenitor cells [179], endothelial progenitor cells-derived EVs protect against angiotensin II-induced cardiac hypertrophy [180], and mesenchymal stem cell EVs reduce infarct size in a mouse model of myocardial ischem”
Using exosomes, naturally-equipped nanocarriers, for drug delivery (2015, background): “It was reported that MSCs-derived exosomes produced significant cardio-protective paracrine effects against myocardial ischemia/reperfusion injury in pig and mouse models [68,69].”
Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction. (2014, background): “These findings are in line with, and expand, the aforementioned data by Lai et al.(18) on exosomes secreted by MSCs, as well as data by Chen et al.”
Brief update on endocytosis of nanomedicines (2019, background): “They are involved in a wide range of intercellular communications, including antigen presentation [165,166], immunomodulation [167,168], tissue repair [169,170], and cancer growth [171,172].”
EVpedia: a community web portal for extracellular vesicles research (2015, background): “The identification of vesicle-specific cargos could help us to unravel the molecular mechanisms underlying the cargo sorting and biogenesis of EVs.”
Advances in therapeutic applications of extracellular vesicles (2019, methodology): “EVs derived from MSCs have been reported to have therapeutic potential in preclinical studies in diverse tissues and indications, including the treatment of diseases and regenerative medicine targeting the lungs (29–31), kidney (32–34), liver (35, 36), central nervous system (37–39), cartilage (40–4”
Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses (2011, background): “Exosomes are secreted by neural, epithelial, muscle and stem cells, and their range of proposed functions include contribution to tissue repair (exosomes secreted by mesenchymal stem cells modify host cardiac tissue) (89), communication within the nervous system (exosomes are secreted by neurons, Sc”
Exosomes: secreted vesicles and intercellular communications (2011, background): “Exosomes from mesenchymal stem cells contribute to tissue repair of host cardiac tissue, and, conversely, lung tissue can release exosomes (or possibly other vesicles) that modify stem cells to promote differentiation of the lung tissue into lung epithelial cells [26,27].”