Using exosomes, naturally-equipped nanocarriers, for drug delivery
By E. Batrakova, M. Kim. Journal of Controlled Release, 2015
986 citations recorded by the source corpus.
Exosomes offer distinct advantages that uniquely position them as highly effective drug carriers. Comprised of cellular membranes with multiple adhesive proteins on their surface, exosomes are known to specialize in cell–cell communications and provide an exclusive approach for the delivery of various therapeutic agents to target cells. In addition, exosomes can be amended through their parental cells to express a targeting moiety on their surface, or supplemented with desired biological activity. Development and validation of exosome-based drug delivery systems are the focus of this review. Different techniques of exosome isolation, characterization, drug loading, and applications in experimental disease models and clinic are discussed. Exosome-based drug formulations may be applied to a wide variety of disorders such as cancer, various infectious, cardiovascular, and neuro-degenerative disorders. Overall, exosomes combine benefits of both synthetic nanocarriers and cell-mediated drug delivery systems while avoiding their limitations.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/0c0a116f0541bce6b9f8a0f53c99db8122f871a6
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Citations in the corpus
- The Smart Drug Delivery System and Its Clinical Potential (2016, background): “For example, exosomes can be directed to specific tissues, while maintaining their biological functions [174-178].”
- Therapeutic Nanoparticles and Their Targeted Delivery Applications (2020, background): “Since these vesicles can be isolated from a patient’s bodily fluids, allogenic exosomes have an advantage over the immune system, which can easily protect the cargo from rapid clearance and improve the drug delivery to targeted sites [80].”
- Engineering exosomes for targeted drug delivery (2021, positive): “Consequently, these naturally-equipped nanocarriers have been used for drug delivery [15].”
- Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments (2022, methodology): “Although ultrafiltration-based isolation methods dispense with the use of specialized equipment like centrifuges, the vesicles are vulnerable to breakage or deformation due to force used, thus, affecting downstream analysis [144].”