Advances in therapeutic applications of extracellular vesicles
By O. Wiklander, Meadhbh Á. Brennan, Jan Lötvall, X. Breakefield, S. El Andaloussi. Science Translational Medicine, 2019
885 citations recorded by the source corpus.
Understanding extracellular vesicle biology and production will pave the way for a new type of biotherapeutic. Extracellular vesicles (EVs) are nanometer-sized, lipid membrane–enclosed vesicles secreted by most, if not all, cells and contain lipids, proteins, and various nucleic acid species of the source cell. EVs act as important mediators of intercellular communication that influence both physiological and pathological conditions. Given their ability to transfer bioactive components and surmount biological barriers, EVs are increasingly being explored as potential therapeutic agents. EVs can potentiate tissue regeneration, participate in immune modulation, and function as potential alternatives to stem cell therapy, and bioengineered EVs can act as delivery vehicles for therapeutic agents. Here, we cover recent approaches and advances of EV-based therapies.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/961bd4eebebfe15f76465d0c181e924a943b9805
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cancer Research
- G. Raposo
- Guillaume van Niel
- P. Vader
- Aled Clayton
- C. Théry
- T. Whiteside
- Marina Colombo
- Raghu Kalluri
In Molecular Biology
- G. Raposo
- Guillaume van Niel
- P. Vader
- Aled Clayton
- C. Théry
- T. Whiteside
- Suresh Mathivanan
- Raghu Kalluri
Citations in the corpus
- Challenges and directions in studying cell–cell communication by extracellular vesicles (2022, background): “EVs are naturally occurring vehicles that are capable of transferring biological cargo, and as such there has been a great deal of interest in their potential applications in drug delivery 91 (Table 2).”