Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro

By B. Reubinoff, M. Pera, C. Fong, A. Trounson, A. Bongso. Nature Biotechnology, 2000

2,790 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c1ed634eed906194e17dce5228f47cece721c39d

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Citations in the corpus

TGFβ/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells (2005, background): “…to mouse embryonic stem cell identity. mESCs are typically cultured in medium containing leukemia inhibitory factor (LIF), a protein that has been shown to maintain mESCs (Smith, 2001), but not hESCs (Thomson et al., 1998; Reubinoff et al., 2000; Sato et al., 2004), in the undifferentiated state.”
Embryonic stem cell differentiation: emergence of a new era in biology and medicine. (2005, background): “The regulation of hES cell growth is less well understood and differs from that of the mouse in that LIF and STAT3 appear to play no role in their self-renewal (Thomson et al. 1998; Reubinoff et al. 2000; Daheron et al. 2004).”
Properties of the amniotic membrane for potential use in tissue engineering. (2008, background): “In addition, they also show high expression of octamer binding protein 4 (Oct-4) and Nanog (Reubinoff et al., 2000; Chambers et al., 2003).”
Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells (2005, background): “…for pluripotency has been shown in numerous studies to accurately predict pluripotency as assayed by teratoma formation in immunocompromised mice (Amit et al., 2000; Amit et al., 2004; Reubinoff et al., 2000; Stojkovic et al., 2004; Thomson et al., 1998; Wang et al., 2005b; Xu et al., 2001).”
Core transcriptional regulatory circuitry in human embryonic stem cells. (2005, background): “…of human ES cells *Correspondence: young@wi.mit.edu 6 These authors contributed equally to this work. provides a unique opportunity to study early development and is thought to hold great promise for regenerative medicine (Pera and Trounson, 2004; Reubinoff et al., 2000; Thomson et al., 1998).”
Control of developmental regulators by Polycomb in human embryonic stem cells. (2006, background): “Human ES cells, which can be propagated in culture in an undifferentiated state but selectively induced to differentiate into many specialized cell types, are thought to hold great promise for regenerative medicine (Thomson et al., 1998; Reubinoff et al., 2000; Mayhall et al., 2004; Pera and Trounso”
The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. (2003, background): “Furthermore, LIF is not required for selfEmbryonic stem (ES) cells derived from inner cell mass renewal of human ES cells (Reubinoff et al., 2000) and of mammalian blastocysts grow rapidly and infinitely several mouse ES cell lines (Berger and Sturm, 1997; while maintaining pluripotency, the…”
Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells. (2003, background): “Taken together, our data suggest that cytokines are able to either (1) direct the differentiation of uncommitted hESCs, and/or (2) induce hematopoietic cell fate from currently uncharacterized hematopoietic precursors arising during stage I of EB development.”
Differences between human and mouse embryonic stem cells. (2004, background): “On the other hand, human ES cells, unlike their mouse counterparts, do not appear to require LIF for their propagation or for maintenance of pluripotency (Reubinoff et al., 2000; Thomson et al., 1998a).”