Effects of age on tissues and regions of the cerebrum and cerebellum.

By Terry L. Jernigan, S. Archibald, Christine Fennema-Notestine, A. Gamst, J C Stout, Julie C. Bonner, J. Hesselink. Neurobiology of Aging, 2001

947 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/c1e8822c0080b3d12f69208b7db485f8c04da36d

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Citations in the corpus

High consistency of regional cortical thinning in aging across multiple samples. (2009, background): “However, cumulative evidence also indicates that brain aging is not uniform, and significant heterogeneity of age effects is observed across brain regions (Raz et al. 1997, 2005; Good et al. 2001; Jernigan et al. 2001; Raz, Gunning-Dixon, et al. 2004; Salat et al. 2004).”
Motor control and aging: links to age-related brain structural, functional, and biochemical effects. (2010, neutral): “Though it is clear that older adults exhibit less gray matter volume in comparison to young adults, the prefrontal cortex is particularly susceptible to gray matter atrophy (Good et al., 2001; Jernigan et al., 2001; Raz et al., 1997, 2004; Resnick et al., 2003).”
The effects of stress and stress hormones on human cognition: Implications for the field of brain and cognition. (2007, background): “Indeed, our results showing that about 25% of 18to 24-year-old individuals present HV as small as those observed in the average older adults aged 60–75 years raise the issue of the significance of the negative association usually obtained between age and HV (Goldstein et al., 2001; Good et al., 2001”
Aerobic fitness reduces brain tissue loss in aging humans. (2003, background): “Average losses are estimated at roughly 15% of the cerebral cortex and 25% of the cerebral white matter between ages 30 and 90 (1), with disproportionately high losses in the frontal, parietal, and temporal cortices (2).”
Regional Frontal Cortical Volumes Decrease Differentially in Aging: An MRI Study to Compare Volumetric Approaches and Voxel-Based Morphometry (2002, result): “In some other studies, the opposite was found; i.e., age-related changes were most obvious in white matter, but only in subjects over 70 years of age (Salat et al., 1999; Courchesne et al., 2000; Jernigan et al., 2001; Salat et al., 2001).”
Prevalence of olfactory impairment in older adults. (2002, background): “Structural magnetic resonance imaging shows age-associated volumeloss inmesial temporal lobeareas important to olfactory processing.(52) Functional magnetic resonance imaging shows less activation in elderly individualsduringolfactoryprocessing,both in mesial temporal lobe areas (C.”
Measures of brain morphology and infarction in the framingham heart study: establishing what is normal. (2005, background): “[41,42]show results similar to those reported here with age related differences being largest for total brain, frontal lobe and temporal brain volumes, whereas age-related differences in parietal and occipital lobe brain volumes were small.”
Marked loss of myelinated nerve fibers in the human brain with age (2003, background): “In vivo studies using MRI also reveal significant age-related losses of white matter volume compared with a much smaller decline in gray matter volume (Albert, 1993; Christiansen et al., 1994; Guttmann et al., 1998; Jernigan et al., 2001).”
Mapping cortical change across the human life span (2003, background): “Recent work has also assessed how normal aging affects brain structur”
Distinct genetic influences on cortical surface area and cortical thickness. (2009, result): “Similarly, we must recognize that given the high degree of developmental change in gray and white matter during childhood and adolescence, these results may not apply to younger age cohorts (Giedd et al. 1999; Jernigan et al. 2001; Sowell et al. 2004; Jernigan and Gamst 2005).”
A meta-analytic review of emotion recognition and aging: implications for neuropsychological models of aging. (2008, background): “Reductions of both white and grey matter tend to be larger in the frontal lobes than in other brain regions (Jernigan et al., 2001; Miech, et al., 2002).”
Frontal-hippocampal double dissociation between normal aging and Alzheimer's disease. (2005, background): “It has been reported that the gray matter losses may precede white matter changes followed by acceleration of white matter degeneration (Miller et al., 1980; Jernigan et al., 2001).”
Sexual dimorphism and asymmetries in the gray-white composition of the human cerebrum (2003, background): “After the age of 50, WM volume typically decreases more quickly than GM volume; thus the GM—WM ratio increases slightly with advanced age (Miller et al., 1980; Jernigan et al., 2001).”
Relationship between hippocampal volume and memory ability in healthy individuals across the lifespan: review and meta-analysis. (2004, background): “…postmortem examination) and volume (from MR studies) are lower in older adults than younger adults (Courchesne et al., 2000; Good et al., 2001; Jernigan et al., 2001; Mueller et al., 1998; Pfefferbaum et al., 1994; Resnick, Pham, Kraut, Zonderman, & Davatzikos, 2003; see Coffey, 2000; Kemper,…”
Life-span changes of the human brain white matter: diffusion tensor imaging (DTI) and volumetry. (2010, background): “Total WM volume peaked at approximately 50 years of age, supporting the notion of WM volume growth until middle age (Jernigan et al. 2001; Allen et al. 2005; Fjell et al. 2005; Walhovd et al. forthcoming).”
One year brain atrophy evident in healthy aging (2009, result): “, 2005, 2009), but discrepant findings regarding thalamus and pallidum have been reported (Jernigan et al., 1991; Gunning-Dixon et al., 1998; Luft et al., 1999; Jernigan et al., 2001; Raz et al., 2003).”