Aerobic fitness reduces brain tissue loss in aging humans.

By Stanley J. Colcombe, Kirk I. Erickson, Naftali Raz, Andrew G. Webb, Neal J. Cohen, E. McAuley, A. Kramer. The journals of gerontology. Series A, Biological sciences and medical sciences, 2003

1,075 citations recorded by the source corpus.

Subfields: Epidemiology, Psychiatry and Mental health, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/88d5c18e2cd3c7b85686f771b048c3833b86a4de

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Citations in the corpus

Plasticity of Brain Networks in a Randomized Intervention Trial of Exercise Training in Older Adults (2010, neutral): “Plasticity of brain networks in a randomized intervention trial of exercise training in older adults”
Aerobic exercise training increases brain volume in aging humans. (2006, background): “In one such study (14), we found that older adults with a lifelong history of cardiovascular exercise had better preserved brains than did age-matched sedentary counterparts.”
Exercise Is Associated with Reduced Risk for Incident Dementia among Persons 65 Years of Age and Older (2006, background): “Our results might be explained by the recent interesting finding that the area of the brain most susceptible to ischemic damage (the hippocampus), which is also one of the earliest areas of the brain to be affected by Alzheimer disease, had less tissue loss in older persons at higher levels of physi”
Exercise Enhances Learning and Hippocampal Neurogenesis in Aged Mice (2005, background): “Indeed, older adults who exercised throughout life had less brain tissue loss than sedentary individuals (Colcombe et al., 2003).”
Aerobic Fitness is Associated With Hippocampal Volume in Elderly Humans (2009, neutral): “Aerobic exercise interventions have been found to reverse decay in prefrontal and lateral temporal regions (Colcombe et al., 2006), and cardiorespiratory fitness levels moderate agerelated declines in volume of the prefrontal and parietal regions (Colcombe et al., 2003).”
Exercise and the brain: something to chew on (2009, background): “Moreover, MRI studies showed that prefrontal and temporal gray matter volume was increased in active elderly subjects as compared with sedentary controls [24].”
A Review of the Effects of Physical Activity and Exercise on Cognitive and Brain Functions in Older Adults (2013, background): “[55] reported that a higher cardiorespiratory fitness level (VO 2max) was associated with a reduced loss of grey and white matter in the frontal, prefrontal, and temporal regions in older adults.”
Motor control and aging: links to age-related brain structural, functional, and biochemical effects. (2010, neutral): “…with higher aerobic fitness levels may have greater brain volume in the areas discussed in Section 3 as being particularly vulnerable to age-related effects, including the prefrontal, superior parietal, and middle/inferior temporal cortices and anterior white matter tracts (Colcombe et al., 2003).”
Differential aging of the brain: patterns, cognitive correlates and modifiers. (2006, neutral): “Nonetheless, the general direction of findings supports the assertion that executive functions and by inference brain structures that support them, are especially sensitive to beneficial effects of aerobic fitness (Colcombe and Kramer, 2003; Colcombe et al., 2003; Lesniak and Dubbert, 2001).”
The mitochondrial energy transduction system and the aging process. (2007, background): “A series of reports documented that the beneficial effects of exercise are extended to other organs, such as the heart (19, 113), kidney (113), liver (113), and brain (39).”
Harnessing neuroplasticity for clinical applications (2011, neutral): “In humans, neuroimaging studies have described a range of anatomic and functional correlates of such effects (Dustman et al., 1990; Colcombe et al., 2003; Pereira et al., 2007; Pontifex et al., 2009; Pajonk et al., 2010).”