Marked loss of myelinated nerve fibers in the human brain with age

By L. Marner, J. Nyengaard, Yong Tang, B. Pakkenberg. The Journal of comparative neurology, 2003

609 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Physiology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/a59bd31d7662557bbe6d172827ce978b7823aefc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Physiology

In Radiology, Nuclear Medicine and Imaging

Citations in the corpus

The Human Connectome Project and Beyond: Initial Applications of 300 mT/m Gradients (2013, background): “Smaller diameter axons are also thought to be the most vulnerable to neurodegeneration associated with aging (Marner et al., 2003).”
Dynapenia and aging: an update. (2012, background): “For example, there are an overwhelming number of morphometric changes in the motor cortex with advancing age, including a dramatic volumetric reduction in the premotor cortex neuron cell body size (66), significant cortical atrophy of areas near the primary motor cortex (67), and a reduction in the ”
Skeletal muscle performance and ageing (2017, neutral): “ences also exist in white matter mass and length of myelinated nerve fibres.(98) Recently, Rosano and colleagues(99)”
White matter changes in Alzheimer’s disease: a focus on myelin and oligodendrocytes (2018, neutral): “For example, the overall hemispheric white matter volume decreases with age [50].”
Gender Differences in Human Brain: A Review (2010, neutral): “At the age of 20, a man has around 176,000 km and a woman, about 149,000 km of myelinated axons in their brains [9].”
Life-span changes of the human brain white matter: diffusion tensor imaging (DTI) and volumetry. (2010, background): “It has been suggested that thin myelinated fibers more proximal to the brain surface or in the periphery of the fasciculi may be more vulnerable to age-related degradation than deeper structures (Sandell and Peters 2001, 2003; Marner et al. 2003; Bartzokis 2004).”
Frontal circuitry degradation marks healthy adult aging: Evidence from diffusion tensor imaging (2005, background): “, 1992) and decline in the number and length of myelinated fibers (Marner et al., 2003).”
Diffusion tensor imaging of adult age differences in cerebral white matter: relation to response time (2004, background): “…the age-related decline in FA is likely to reflect microstructural changes in the cerebral white matter, such as a frank loss of myelinated axons (Marner et al., 2003) and more subtle disruptions of myelin sheaths and the cytoskeletal components of axons (Peters and Sethares, 2002), which are…”
The Cellular and Molecular Landscapes of the Developing Human Central Nervous System (2016, positive): “Equally remarkable, the cerebral white matter of young adults contains approximately 149,000 to 176,000 km of myelinated axons connecting these neurons (Marner et al., 2003).”
Differential aging of the brain: patterns, cognitive correlates and modifiers. (2006, neutral): “…and the cerebellum (Ellis, 1920; Nairn et al., 1989), loss of myelinated fibers across the subcortical cerebrum (Pakkenberg and Gundersen, 1997; Marner et al., 2003; Meier- Ruge et al., 1992), shrinkage and dysmorphology of neurons (Haug, 1985), accumulation of lipofuscin (Terman and Brunk,…”
Regional specificity of MRI contrast parameter changes in normal ageing revealed by voxel-based quantification (VBQ) (2011, background): “…of widespread MT decreases in subcortical WM areas is in line with histopathological findings demonstrating age-related WM changes caused by dysfunctional repair/production in small diameter myelinated fibres (Marner et al., 2003; Pakkenberg and Gundersen, 1997; Peters, 2002; Tang et al., 1997).”
Resting-state EEG correlates of sustained attention in healthy ageing: Cross-sectional findings from the LEISURE study. (2024, background): “…slowing of IAF may be explained by its susceptibility to conduction delays in thalamo-cortical pathways (Roberts and Robinson, 2008; Robinson et al., 2001) and link to white matter structure (Vald ´ es-Hern ´ andez et al., 2010), known to degenerate in ageing (Bartzokis, 2004; Marner et al., 2003).”