Transport of molecules across tumor vasculature

By Rakesh K. Jain. Cancer Metastasis Review, 2004

675 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c135c0240a28ec2aedcf38f9d166c4cdae34dfd5

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In Biomedical Engineering

In Cancer Research

In Molecular Biology

Citations in the corpus

Transport of drugs from blood vessels to tumour tissue (2017, neutral): “c = c0(1 − x/dp) for x ≤ dp, where dp = uc0/Vm (3)”
Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model. (2007, background): “The leaky vessels in tumors lack permselectivity and are unable to sustain the hydrostatic and oncotic pressure gradients across the vessel wall (2, 3).”
High interstitial fluid pressure — an obstacle in cancer therapy (2004, background): “In 1987, Jain hypothesized that the osmotic pressure in tumours must be high and that the high tumour interstitial fluid pressure (IFP) is a barrier for efficient drug deliver”
Delivering nanomedicine to solid tumors (2010, background): “In addition, in tumors, vessel-wall structure is abnormal with wide interendothelial junctions, an abnormally thick or thin basement membrane, large numbers of fenestrae and transendothelial channels formed by vesicles”
A history of the study of solid tumour growth: The contribution of mathematical modelling (2004, background): “Further, tumour cords represent an interesting subject for theoretical investigation, since their simple cylindrical geometry renders them a tractable subunit of a vascular tumour, which, as a whole, comprises a highly heterogeneous agglomeration of various cell types (both normal and neoplastic, in”
Tumor microenvironment abnormalities: Causes, consequences, and strategies to normalize (2007, background): “Diffusion is considered to be the major form of transvascular transport in tumors [Jain, 1987].”
The role of mechanical forces in tumor growth and therapy (2014, neutral): “As a result, the openings in the tumor vessel wall can be as large as a few micrometers in size, much larger than the pores of normal vessels, which are less than 10nm (65-67).”
Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization. (2007, background): “Diffusion is considered to be the major form of transvascular transport in tumors (Jain, 1987).”
Vascularization Strategies for Tissue Engineering (2009, positive): “121,129 Nevertheless, the general equations and methods described above provide a basic framework for modeling oxygen distribution within 3D tissue constructs.”
Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. (2014, background): “While molecules smaller than 4 nm can diffuse back to the blood circulation and be reabsorbed [48-50], the diffusion of macromolecules or NPs is hindered by their larger hydrodynamic radii.”