Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model.

By Rakesh K. Jain, Ricky T. Tong, Lance L. Munn. Cancer Research, 2007

611 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/e1409d7e25cfeed36b0a6d35024897ee63d6292d

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Citations in the corpus

The role of mechanical forces in tumor growth and therapy (2014, neutral): “Taken together, the effects of elevated IFP make it a major barrier to drug delivery (19-23).”
Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come (2016, background): “In contrast, free DOX is distributed throughout the body, but its movement toward the tumor is restricted by the tumor interstitial hypertension, which decreases the free drug’s ability to enter tumor tissue (Jain, 1987; Jain et al., 2007).”
Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers. (2013, background): “This fluid not only causes peritumor edema but also carries growth factors and cancer cells with it, further fueling tumor progression.(64,65) Finally, as stated earlier, excessive leakiness and vascular compression cause flow stasis in tumor vessels, resulting in hypoxia, which further upregulates ”
Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization. (2007, background): “Steps of lymphatic metastasis and the effect of anti-lymphangiogenic treatment Elevated tumor IFP increases interstitial fluid flow at the tumor margin (Jain et al., 2007).”
Delivering nanomedicine to solid tumors (2010, background): “These peritumor lymphatics carry fluid, growth factors and cancer cells, and mediate tumor metastases via the lymphatic network ( Figure 2a )”
Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles. (2013, background): “tortuous and chaotic vasculature of tumors represents a barrier to drug delivery because there is limited perfusion [65, 79-81].”