Vascularization Strategies for Tissue Engineering

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Vascularized Bone Tissue Engineering: Approaches for Potential Improvement (2012, background): “Microscale technologies hold a great promise in creating vascularized networks within engineered tissue constructs.(9,169,170) To date, numerous approaches such as micropatterning, microcontact printing, and micromolding have been widely adopted in the development of in vitro microscale vascularized”
In situ Forming Injectable Hydrogels for Drug Delivery and Wound Repair (2018, neutral): “Because supply of nutrients and dissolved gasses at levels sufficient to promote long term survival of tissues is limited to a distance of 200 μm from the supplying vessel, sufficient vessel formation throughout reforming tissues has limited the efficacy of many therapeutic systems [87].”
Review of bioactive glass: from Hench to hybrids. (2013, background): “When a porous scaffold is used, transport of oxygen and nutrients is initially dependent on diffusion, which is limited to a few hundred micrometres from vessels, so new vessels must be produced and they must penetrate the porous scaffold [273].”
Tissue Engineering for Clean Meat Production (2019, background): “ECs can form these networks under appropriate culture conditions (Lovett et al., 2009), such as co-culture with mural cells (Sims, 1986; Allt and Lawrenson, 2001; Bergers and Song, 2005; von Tell et al.”