Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1

By L. Gu, S. Tseng, Renée M Horner, Carmen Tam, M. Loda, B. Rollins. Nature, 2000

920 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/c1232e0105142b9fb0dacd61716e0adfb3c75cd2

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In Hematology

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In Immunology

Citations in the corpus

Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment (2014, background): “Tumor-derived CCL2 acts as a potent factor for Th2 polarization and shifts monocytes toward the M2-polarized macrophages [24,25].”
Alternative activation of macrophages (2003, background): “CCL2 is essential for T H 2 responses, and its overexpression is associated with defects in cell-mediated immunit”
Chemotaxis in cancer (2011, background): “These chemokines, as well as producing large amounts of arginase, serve to inactivate T cell effector functions and contribute further towards a T helper 2 (T H 2)-polarized immunit”
Chemokines and disease (2001, result): “Although these results may appear to contradict recent reports of the importance of MCP-1 in mounting T helper 2 (T H 2) response”
Inflammatory and immune pathways in the pathogenesis of periodontal disease (2014, neutral): “affecting is presented in Table 2 (21, 37, 64, 74, 101, 110, 146, 147, 200, 208, 209, 249, 264, 267).”
Chemokines as regulators of T cell differentiation (2001, background): “Animals that lack CCL2 show diminished T cell responses with stronger effects on T H 2-type response”
Cancer and the chemokine network (2004, background): “Type-2 macrophages also release CCL2, which could contribute to T H 2-polarized immunit”
International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors (2014, neutral): “Ccl2 was shown to favor Th2 polarization (Gu et al., 2000), and Ccl2deficient animals have been reported to have reduced airway hyperreactivity and to be resistant to allergeninduced asthma (Campbell et al.”
Chemokines: immunology's high impact factors (2001, neutral): “CCL2-deficient mice are also unable to initiate immunoglobulin E (IgE) class switching and are resistant to infection by Leishmania major”
Absence of Monocyte Chemoattractant Protein 1 in Mice Leads to Decreased Local Macrophage Recruitment and Antigen-Specific T Helper Cell Type 1 Immune Response in Experimental Autoimmune Encephalomyelitis (2001, background): “MCP-1 2 / 2 mice of Balb/c strain were relatively resistant to Leishmania major infection, indicating that lack of MCP-1 led to reduced Th2 immunity (11).”