The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells.

By Mohammed Bensaid, M. Gary‐Bobo, A. Esclangon, J. Maffrand, G. Fur, F. Oury-Donat, P. Soubrié. Molecular Pharmacology, 2003

638 citations recorded by the source corpus.

Subfields: Pharmacology, Physiology

View Paper: https://www.semanticscholar.org/paper/c8e4b45df168831a13aa77a62382d35e4d2d12ca

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The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Pharmacology

1. V. Di Marzo
2. George Kunos
3. P. Pacher
4. S. Batkai
5. K. Mackie
6. G. Marsicano
7. B. Lutz

In Physiology

1. P. Pacher
2. M. Maj

Citations in the corpus

• Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemia. (2006, background): “White adipocytes do express functional CB1 receptors, whose levels are higher in obese rats and whose blockade leads to increased levels of adiponectin (13, 17), an adipokine that enhances insulin sensitivity and glucose and lipid metabolism (18).”
• The emerging role of the endocannabinoid system in endocrine regulation and energy balance. (2006, background): “The quick and strong improvement of hyperinsulinemia detected after a very short-term treatment with SR141716 (4 d) in obese Zucker rats was also attributed to an increase in adiponectin (59).”
• Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. (2005, background): “The upregulation of hepatic CB1 observed in mice on the high-fat diet is reminiscent of the reported upregulation of CB1 expression in adipose tissue from genetically obese versus lean rats (18) and could involve similar underlying mechanisms.”
• The Endocannabinoid System as an Emerging Target of Pharmacotherapy (2006, background): “Conversely, rimonabant increases adiponectin secretion by adipocytes (Bensaid et al., 2003) and adiponectin plasma levels in obese human subjects (Després et al., 2005), which should lead to increased lipid β-oxidation and thermogenesis in vivo.”
• Endocannabinoid control of food intake and energy balance (2005, background): “, whereas its blockade causes up-regulation both in vitro and in vivo”