Adiponectin: more than just another fat cell hormone?

By M. Chandran, S. Phillips, T. Ciaraldi, R. Henry. Diabetes Care, 2003

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How researchers see this paper

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The metabolic syndrome: time for a critical appraisal (2005, positive): “It is now well established that there is a strong and consistent inverse association between adiponectin and both insulin resistance and inflammation [70, 82, 83].”
Mechanisms of obesity-associated insulin resistance: many choices on the menu. (2007, background): “Adiponectin is structurally related to complement 1q, is specifically expressed in differentiated adipocytes, and circulates at high levels in the bloodstream (Chandran et al. 2003).”
The emerging role of the endocannabinoid system in endocrine regulation and energy balance. (2006, background): “Finally, the increase in levels of adiponectin in Zucker obese rats chronically treated with SR141716 in vivo (59) and in 3T3 F442A adipocytes acutely stimulated with the CB1 receptor antagonist in vitro (59) points to a close relationship between CB1 receptor blockade and the production of this ant”
Protein quality control in the early secretory pathway (2008, background): “…adiponectin oligomerization Another example of sequential QC comes from adiponectin, a plasma protein secreted by adipocytes (Scherer et al, 1995; Chandran et al, 2003), low levels of which associate with diabetes and cardiovascular diseases (Hotta et al, 2000; Phillips et al, 2003; Shetty et…”