Extension of life-span with superoxide dismutase/catalase mimetics.

By S. Melov, Joanne Ravenscroft, Sarwatt Malik, M. Gill, D. Walker, Peter E. Clayton, Douglas C. Wallace, B. Malfroy, S. Doctrow, G. Lithgow. Science, 2000

940 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/bfce0455267705b7c622a72b1a4cfc1a512ef1f1

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Citations in the corpus

• Oxidants, oxidative stress and the biology of ageing (2000, background): “Additional evidence for a link between longevity and oxidative stress resistance in the nematode has recently been obtained using a pharmacological approach to boost antioxidant defence”
• Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. (2001, unknown): “elegans [88].”
• Production, characterization and In vitro antioxidant activities of exopolysaccharide from Weissella cibaria GA44 (2018, background): “Accumulation of these ROS in cells, or their increase as a result of environmental stress may cause damage to DNA, RNA, and proteins, and may even leads to cell death (Melov et al., 2000).”
• The sites and topology of mitochondrial superoxide production (2010, background): “elegans (Melov et al., 2000), but only under specific conditions (Keaney and Gems, 2003).”
• Trends in oxidative aging theories. (2007, background): “In a study highly supportive of the free radical theory of aging, Lithgow's group published that the catalytic antioxidants (SOD/catalase mimetics) markedly extend life span of C. elegans [72].”
• How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis). (2010, background): “…lifespan (Harrington and Harley, 1988; Phillips et al., 1989; Orr and Sohal, 1994; Parkes et al., 1998; Melov et al., 1999; Adachi and Ishii, 2000; Melov et al., 2000; Moskovitz et al., 2001; Bakaev and Lyudmila , 2002; Ruan et al., 2002; Ishii et al., 2004; Huang et al., 2006; Zou et al., 2007;…”
• Free radicals in the physiological control of cell function. (2002, background): “elegans (566), and synthetic compounds exhibiting both SOD- and catalase-like activities enhance the mean life span of wild-type worms by 44% (388).”
• Calorie restriction and aging: review of the literature and implications for studies in humans. (2003, background): “Similar results were obtained in Caenorhabditis elegans with low-molecular-weight synthetic superoxide dismutase and catalase mimetics (84).”
• Life and death: metabolic rate, membrane composition, and life span of animals. (2007, background): “elegans (230) has been unable to be repeated by others either for C.”