Normal gut microbiota modulates brain development and behavior

By R. Heijtz, Shugui Wang, F. Anuar, Y. Qian, B. Björkholm, Annika Samuelsson, M. Hibberd, Hans Forssberg, S. Pettersson. Proceedings of the National Academy of Sciences of the United States of America, 2011

2,978 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Molecular Biology, Social Psychology

View Paper: https://www.semanticscholar.org/paper/bf91f4ae12b2356f062625e96c69edfa9623bef0

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Citations in the corpus

The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems (2015, background): “These animals generally show a decreased anxiety [23,24,31-33] and an increased stress response with augmented levels of ACTH and cortisol [31,34].”
Microbiota in health and diseases (2022, background): “An epigenetic study using GF mouse models had demonstrated that GF mice showed significant difference in gene expression in the brain systems when compared with control mice, notably in the areas of cortex, cerebellum, striatum, and hippocampus.(261) It is suggested that the gut-brain axis may be af”
The gut microbiota influences blood-brain barrier permeability in mice (2014, background): “The effects of the gut microbiota on brain physiology include synaptogenesis, regulation of neurotransmitters and neurotrophic factors such as brain-derived neurotrophic factor and nerve growth factor-A1 (6).”
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve (2011, background): “Moreover, it has been shown that the absence and/or modification of the gut microflora in mice affects the hypothalamic–pituitary–adrenal (HPA) axis response to stress (6, 7) and anxiety behavior (8, 9), which is important given the high comorbidity between functional gastrointestinal disorders and ”
Kynurenine pathway metabolism and the microbiota‐gut‐brain axis (2017, background): “One of the remarkable features of the gut microbiota is the impact on gene expression in the CNS as indicated, for example, by studies in GF animals (Diaz Heijtz et al., 2011; Stilling et al., 2015c).”
Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration (2017, background): “Using a genome-wide transcriptomic approach Diaz Heijtz and colleagues (2011) demonstrated that germ-free mice have an upregulation of genes associated with a variety of plasticity and metabolic pathways including synaptic long-term potentiation, steroid hormone metabolism, and cyclic adenosine 5-ph”
Dysbiosis of the gut microbiota in disease (2015, background): “Accordingly, intestinal microbiota may have implications on the development and function of the CNS (78, 79).”
Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis (2016, background): “Interestingly, these animals also displayed a reduction in brain-derived neurotrophic factor messenger RNA levels and reduced expression of the synaptic signalling genes PSD-95 and synaptophysin in regions of the brain responsible for motor control and anxiety such as the striatum [104].”