Rb targets histone H3 methylation and HP1 to promoters

By S. Nielsen, Robert Schneider, U. Bauer, Andrew J. Bannister, Ashby J. Morrison, D. O’Carroll, R. Firestein, M. Cleary, T. Jenuwein, R. E. Herrera and 1 more. Nature, 2001

955 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/bf8a61fc0dc16ea0439b0ffd7fc7f4fc71ed0058

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Yi Zhang
2. D. Reinberg
3. C. D. Allis
4. Yang Shi
5. T. Jenuwein
6. Tony Kouzarides
7. J. Whetstine
8. François Fuks

In Oncology

1. D. Cobrinik
2. Antonio Giordano
3. C. Giacinti
4. Roderick J. O’Sullivan
5. K. Helin
6. Tony Kouzarides

Citations in the corpus

• The E2F transcriptional network: old acquaintances with new faces (2005, background): “The elevated expression of E2F target genes, such as cycA, cycE and cycD1 in cells lacking Suv39h, supports the idea that histone methylation is an important mechanism of repression (Nielsen et al., 2001; Ait-Si-Ali et al., 2004).”
• RB and cell cycle progression (2006, background): “…chromatin remodeling factors such as histone deacetylase 1 (HDAC1) (Luo et al., 1998), SWI/SNF factors (Harbour and Dean, 2000; De Luca et al., 1997), Polycomb group proteins (Dahiya et al., 2001) or methyltransferase (Nielsen et al., 2001) that act on the nearby surrounding nucleosome structure.”
• The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase. (2003, methodology): “not restricted to constitutive heterochromatin as it is also recruited to euchromatic genes, such as cyclin E, to silence gene expression (15).”
• Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. (2006, background): “In contrast, H3-K9 promoter methylation is Cell 125, 467–481, May 5, 2006 ª2006 Elsevier Inc. 467 considered a repressive mark for euchromatic genes (Nielsen et al., 2001; Shi et al., 2003) and is also one of the landmark modifications associated with heterochromatin (Nakayama et al., 2001; Peters…”
• Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9 (2002, neutral): “Dm_MSL3(449-503)_P50536 Dm_MSL3(35-88)_P50536 Dm_MOF(395-447)_O02193 Hs_CHD4-d2(621-674)_Q14839 Hs_CHD3-d2(630-683)_Q12873 Mm_CHD1-d2(386-442)_P40201 Hs_CHD4-d1(518-578)_Q14839 Hs_CHD3-d1(525-585)_Q12873 Hs_CHD2-d1(284-342)_O14647 Mm_CHD1-d1(293-351)_P40201 Hs_Tscdy(6-59)_AF080597 At_CMT1(339-392)_O”
• Histone and chromatin cross-talk. (2003, background): “recently, it was shown that several transcription factors are able to recruit proteins or protein complexes containing HMT activity to specific sites of the genome ([65–67].”
• Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects. (2002, background): “EF2) as initiation sites for silencing (Nielsen et al., 2001).”
• The E2F family: specific functions and overlapping interests (2004, background): “Challenging this model, however, is the fact that endogenous pRB has not been found on any human E2F target promoter during the normal cell cycle, and rarely on mouse promoters (Takahashi et al, 2000; Wells et al, 2000; Nielsen et al, 2001; Narita et al, 2003).”
• Review Histone Methylation: Dynamic or Static? (2002, background): “One such case is the cyclin E promoter, whose Furthermore, it is possible that a methylated histone tail may render the histone more or less susceptible to an activity is repressed by K9 H3 methylation in the G1 phase of the cell cycle (Nielsen et al., 2001).”
• ncRNA- and Pc2 Methylation-Dependent Gene Relocation between Nuclear Structures Mediates Gene Activation Programs (2011, positive): “Furthermore, Suv39h1 forms a complex with pRb/ E2F1 and plays a role in the dynamic regulation of specific cell-cycle genes needed for entry into the S phase (Ait-Si-Ali et al., 2004; Nielsen et al., 2001).”
• G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. (2002, background): “Existing data support the notion that H3-K9 methylation may contribute to transcriptional repression (Firestein et al. 2000; Litt et al. 2001; Nakayama et al. 2001; Nielsen et al. 2001; Noma et al. 2001; Vandel et al. 2001).”
• Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin. (2008, positive): “Furthermore, pRb associates with and regulates the HMTs SUV39H1 and Suv4-20h responsible for H3K9 methylation and H4K20me3, respectively (Nielsen et al. 2001; Gonzalo et al. 2005; Isaac et al. 2006).”