The E2F transcriptional network: old acquaintances with new faces

By D. Dimova, N. Dyson. Oncogene, 2005

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Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway (2010, background): “Importantly, mutations in the RB-E2F cascade are found in a wide range of tumor types [36,37].”
GATHER: a systems approach to interpreting genomic signatures (2006, background): “Thus, the roles of E2F in normal function and in tumorigenesis are growing, and its functions and regulatory mechanisms are areas of intense investigation (Nevins, 1998; Dimova and Dyson, 2005).”
Dynamical analysis of a generic Boolean model for the control of the mammalian cell cycle (2006, background): “The corresponding regulatory network is described in the last chapter of the introduction, together with citations of the most relevant experimental articles (for a didactic introduction to cell cycle modelling, see Fuß et al. , 2005).”
Pocket proteins and cell cycle control (2005, background): “A fundamental addition to the early model came with the recognition that pRB and E2F are members of protein families, consisting of the pRB, p107, and p130 pocket proteins, E2F1–7, and the DP1 and DP2-binding partners of E2F1–6 (Cobrinik, 1996; Dyson, 1998; Nevins, 1998; Dimova and Dyson, 2005).”