Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin.

By T. Dechat, Katrin Pfleghaar, K. Sengupta, Takeshi Shimi, D. Shumaker, L. Solimando, Robert D. Goldman. Genes & Development, 2008

1,024 citations recorded by the source corpus.

Over the past few years it has become evident that the intermediate filament proteins, the types A and B nuclear lamins, not only provide a structural framework for the nucleus, but are also essential for many aspects of normal nuclear function. Insights into lamin-related functions have been derived from studies of the remarkably large number of disease-causing mutations in the human lamin A gene. This review provides an up-to-date overview of the functions of nuclear lamins, emphasizing their roles in epigenetics, chromatin organization, DNA replication, transcription, and DNA repair. In addition, we discuss recent evidence supporting the importance of lamins in viral infections.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/30b2e2c124649cbe5121e0522ff48c8fcd3af832

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Citations in the corpus

Human iPSC-based Modeling of Late-Onset Disease via Progerin-induced Aging (2013, neutral): “…some of the normal scaffolding functions of lamin A, which in turn interferes with multiple processes in the nucleus, including chromatin organization, heterochromatin formation, the DNA-damage response, cell cycle, gene transcription, and telomere maintenance (reviewed in Dechat et al., 2008).”
Lamin B1 loss is a senescence-associated biomarker (2012, methodology): “Mice were treated and mRNA was collected and analyzed as described in Figure 4F.”
Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus (2009, background): “Lamins have a central role in the control of nuclear organization and gene functio”
The hallmarks of aging. (2013, background): “Nuclear Architecture Defects in the nuclear lamina can also cause genome instability (Dechat et al., 2008).”