Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9

By P. R. Nielsen, D. Nietlispach, H. Mott, J. Callaghan, Andrew J. Bannister, Tony Kouzarides, Alexey G. Murzin, N. V. Murzina, E. Laue. Nature, 2002

665 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/82eb92d32fe81a83010221b378f0fdd35f473e39

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In Molecular Biology

1. S. Khorasanizadeh
2. Yi Zhang
3. C. D. Allis
4. W. Fischle
5. Yanming Wang
6. J. Min
7. E. Bernstein
8. R. Xu

Citations in the corpus

• Molecular Interplay of the Non-coding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a (2010, neutral): “The structure is similar to that of other chromodomains bound to H3 peptides including mouse HP1bCD/H3K9me2 and 668 Molecular Cell 38, 662–674, June 11, 2010 ª2010 Elsevier Inc. Drosophila PcCD/H3K27me3 (Fischle et al., 2003; Jacobs and Khorasanizadeh, 2002; Min et al., 2003; Nielsen et al., 2002).”
• RNA meets chromatin. (2005, background): “Moreover, atomic structures of both protein–peptide complexes have been determined, which suggest a common binding fold using two features: (1) The H3 peptide itself binds by inserting itself as a missing “rung” in a -stranded core architecture; and (2) the positively charged methyl ammonium ion is ”
• Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. (2002, methodology): “…of K27 (KAARKS) resembles (B) GST-PC or GST beads were incubated with recombinant histone that of K9 (QTARKS) but HP1 binds weakly to a methyl-H3 (wt) methylated with HIM or acetylated with GCN5 (WTac) to ated K27 peptide (Nielsen et al., 2002; Jacobs and Khor-the same specific radioactivity.”
• Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27. (2003, background): “The structure of the HP1 chromodomain in complex with a methyl-Lys 9 histone H3 peptide has been determined recently (Jacobs and Khorasanizadeh 2002; Nielsen et al. 2002).”
• Ki-67: more than a proliferation marker (2018, background): “Via its methyllysinebinding chromodomain, HP1 binds to the hallmark of constitutive heterochromatin, di- and tri-methylated histone H3K9 residues (Jacobs and Sepideh 2002; Nielsen et al. 2002).”