A single type of progenitor cell maintains normal epidermis
By E. Clayton, David P. Doupé, Allon M. Klein, D. Winton, Benjamin D. Simons, P. Jones. Nature, 2007
839 citations recorded by the source corpus.
According to the current model of adult epidermal homeostasis, skin tissue is maintained by two discrete populations of progenitor cells: self-renewing stem cells; and their progeny, known as transit amplifying cells, which differentiate after several rounds of cell division. By making use of inducible genetic labelling, we have tracked the fate of a representative sample of progenitor cells in mouse tail epidermis at single-cell resolution in vivo at time intervals up to one year. Here we show that clone-size distributions are consistent with a new model of homeostasis involving only one type of progenitor cell. These cells are found to undergo both symmetric and asymmetric division at rates that ensure epidermal homeostasis. The results raise important questions about the potential role of stem cells on tissue maintenance in vivo.
Subfields: Cell Biology, Dermatology, Urology
View Paper: https://www.semanticscholar.org/paper/bf7b932831c2ec294516aca45a0cc5ba652255ea
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cell Biology
In Dermatology
In Urology
Citations in the corpus
- Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling (2010, background): “The latter group includes cells that are relatively quiescent and become activated during injury and repair, as well as other stem cells that periodically leave the bulge to participate in the regeneration of the hair follicle (Clayton et al., 2007; Zhang et al., 2009; Snippert et al., 2010).”
- Experience dictates stem cell fate in the adult hippocampus. (2011, positive): “…with this notion, indelible lineage analyses from several adult nonneuronal stem cell systems have suggested that changes in the stem cell niche result in modified lineage trajectories and tissue homeostasis (Clayton et al., 2007; Jones et al., 2007; Nakagawa et al., 2007; Ying et al., 2008).”
- No place like home: anatomy and function of the stem cell niche (2008, background): “, although they do not appear to be necessary for normal, homeostatic replacement of epidermal cell”
- Structure and functions of keratin proteins in simple, stratified, keratinized and cornified epithelia (2009, methodology): “Another issue is whether keratinocytes are still mitotically active or not, although the models by Alonso & Fuchs (2003) and Clayton et al. (2007) assume that they are not as indicated by the production of K1/K10 instead of K5/K14.”
- Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. (2010, neutral): “For at least two cases, the long-lived keratinocyte progenitor in the basal layer of the epidermis (Clayton et al., 2007) and the germline stem cells in mammalian testis (Klein et al.”
- An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control (2014, background): “in the skin, the Wnt-responding IFE stem cells appear to divide stochastically to generate proliferating and differentiating daughter cells with equal probability (44, 60).”
- Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. (2008, background): “Fate-mapping studies of muscle satellite cells (Kuang et al., 2007), spermatogonial stem cells (Nakagawa et al., 2007), epidermal stem cells (Clayton et al., 2007), (A and B) Adult hematopoietic stem cells (HSCs) reside primarily within bone marrow.”
- Epidermal homeostasis: a balancing act of stem cells in the skin (2009, background): “By contrast, when the division plane is parallel to the basement membrane, as occurs in adult tail ski”