Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing Bodies

By Ujwal Sheth, R. Parker. Science, 2003

1,441 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bef5c57e19d0f7f4c9295aaa08a708afcaf15910

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In Molecular Biology

1. R. Parker
2. R. Pillai
3. Elisa Izaurralde
4. Paul Anderson
5. N. Kedersha
6. C. Brangwynne
7. Ujwal Sheth
8. A. Eulalio

Citations in the corpus

• A role for the P-body component GW182 in microRNA function (2005, background): “Recent observations have also led to an alternative model for silencing by microRNAs wherein mRNA interactions with RISC might sequester targeted mRNAs in P-/GW-bodie”
• Mammalian stress granules and processing bodies. (2007, background): “Many fundamental studies of PBs have been performed in yeast (Sheth and Parker, 2003; Teixeira et al., 2005).”
• P-Body Purification Reveals the Condensation of Repressed mRNA Regulons. (2017, background): “Yet decapping losses of function were shown to increase P-body size (Aizer et al., 2014; Franks and Lykke-Andersen, 2007; Sheth and Parker, 2003), leading to the idea that P-bodies were a site of decay.”
• Stress granules and processing bodies are dynamically linked sites of mRNP remodeling (2005, methodology): “As PBs are putative sites of 5 –3 mRNA degradation (Sheth and Parker, 2003; Cougot et al., 2004a), the juxtaposition of the two structures during arsenite treatment (Fig.”
• The DEAD-box protein family of RNA helicases. (2006, background): “In eukaryotes, the yeast Dhh1 protein was found to be required for decapping and to be associated with 3′ to 5′ degradation in the cytoplasm (Coller et al., 2001; Sheth and Parker, 2003).”
• Cytoplasmic foci are sites of mRNA decay in human cells (2004, background): “, 2002), while related structures where subsequently observed in yeast (Sheth and Parker, 2003).”
• N6-methyladenosine Modulates Messenger RNA Translation Efficiency (2015, neutral): “The human YTH domain family protein 2 (YTHDF2) has been shown to affect the stability of mA-modified RNA by localizing them to mRNA decay sites (Sheth and Parker, 2003; Wang et al., 2014a).”
• How do microRNAs regulate gene expression? (2008, background): “Thus, the foci disappear in yeast mutants with defective deadenylation, which would reduce the level of decay intermediates, and increase in size and number in mutants defective in downstream steps of the decay process, such as mutants in the Dcp1/Dcp2 decapping complex or the Xrn1 5′→3′ exonuclease”
• P-bodies and stress granules: possible roles in the control of translation and mRNA degradation. (2012, background): “This possibility is supported by the observation that P-bodies increase in number and size when mRNA decay is inhibited at the stage of decapping by deletion of Dcp1 or after decapping by the deletion of Xrn1 (Sheth and Parker 2003; Cougot et al. 2004).”
• m6A-dependent regulation of messenger RNA stability (2013, neutral): “6a–j) 9,26 .”
• MicroRNA function: multiple mechanisms for a tiny RNA? (2005, background): “Most importantly, the PIWI domain of two archaeal proteins was shown to have a fold similar to that of RNase H (Parker et al. 2004; Song et al. 2004), an enzyme that cleaves the RNA strand in DNA–RNA hybrids.”