Vascular niche for adult hippocampal neurogenesis

By T. Palmer, Andrew R. Willhoite, Fred H. Gage. 2000

1,926 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Developmental Neuroscience

In Neurology

Citations in the corpus

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “In the adult SGZ, dense clusters of dividing cells were found to be anatomically close to the vasculature, especially capillaries (Palmer et al., 2000).”
BRAIN REGENERATION IN PHYSIOLOGY AND PATHOLOGY: THE IMMUNE SIGNATURE DRIVING THERAPEUTIC PLASTICITY OF NEURAL STEM CELLS (2011, background): “From an anatomical point of view, NPCs residing within the SGZ form clusters with endothelial cells at the level of capillary tips (168) while the SVZ niche contains a planar vascular plexus and proliferating type B and type C cells that are apposed to blood vessels (150, 215, 227).”
Irradiation induces neural precursor-cell dysfunction (2002, methodology): “A previous study using ionizing radiation to induce DNA damage demonstrated that the methods used in this work are not sensitive enough to detect BrdU incorporated during DNA repai”
Exercise Enhances Learning and Hippocampal Neurogenesis in Aged Mice (2005, background): “In the dentate gyrus, new cells are clustered close to blood vessels (Palmer et al., 2000) and proliferate in response to vascular growth factors (Jin et al., 2002).”
The Adult Substantia Nigra Contains Progenitor Cells with Neurogenic Potential (2002, background): “These BrdU/nestin-positive cells were not associated with blood vessels, indicating that these cells were neural progenitor cells and not endothelial cells, which have been described to express nestin in the adult CNS (Kobayashi et al., 1998; Palmer et al., 2000).”
Reduced Hippocampal Neurogenesis in Adult Transgenic Mice with Chronic Astrocytic Production of Interleukin-6 (2002, background): “It has been shown recently that proliferating cells in the subgranular zone of the dentate gyrus constitute a mixed population of endothelial cells and neural precursors (Palmer et al., 2000).”
Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. (2008, background): “Endothelial cells secrete factors that promote the self-renewal of normal neural stem cells in culture (Shen et al., 2004), and dividing neural progenitors sometimes reside close to blood vessels in the brain (Palmer et al., 2000).”
Reversible effect of X‐irradiation on proliferation, neurogenesis, and cell death in the dentate gyrus of adult mice (2007, neutral): “Irradiation ablates proliferation of dentate gyrus cells both in vitro (Palmer et al., 2000) and in vivo (Monje et al., 2002), leading to reduced AhN.”
Functional neurogenesis in the adult hippocampus (2002, background): “A portion of these cells may be associated with the vasculatur”
Astroglia induce neurogenesis from adult neural stem cells (2002, background): “In contrast, a feeder layer of primary fibroblasts derived from rat ski”