Irradiation induces neural precursor-cell dysfunction

By Michelle Monje, S. Mizumatsu, J. Fike, T. Palmer. Nature Medicine, 2002

1,273 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Genetics, Neurology

View Paper: https://www.semanticscholar.org/paper/2abfbe538eebc8c0ebfbdb4be23fcea456bee1db

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

1. Fred H. Gage
2. Hongjun Song
3. Guo-li Ming
4. R. Duman
5. R. Hen
6. Wei Deng
7. Sebastian Jessberger
8. J. Snyder

In Genetics

1. Fred H. Gage
2. Hongjun Song
3. Guo-li Ming
4. T. Palmer
5. P. Carpentier
6. Sebastian Jessberger
7. R. Hen
8. R. Duman

In Neurology

1. Fred H. Gage
2. Hongjun Song
3. Guo-li Ming
4. R. Duman
5. T. Palmer
6. D. Abrous
7. J. Snyder
8. P. Carpentier

Citations in the corpus

• Reversible effect of X‐irradiation on proliferation, neurogenesis, and cell death in the dentate gyrus of adult mice (2007, positive): “In comparison with previous studies (Monje et al., 2002; Santarelli et al., 2003; Rola et al., 2004), the rate at which we exposed the brain (i.”
• Radiation-Induced Cognitive Impairments are Associated with Changes in Indicators of Hippocampal Neurogenesis (2004, background): “Given the extreme sensitivity of neurogenesis to low to moderate doses of X rays (24, 25), and the persistent reductions in specific cellular elements associated with neurogenesis at the time of cognitive testing (Fig.”
• Excitation-neurogenesis coupling in adult neural stem/progenitor cells. (2004, background): “…Neurogenesis from Adult NPCsendogenous NPCs when implanted into the intact hippocampus, participating normally in hippocampal neuro- We next investigated the impact of excitation on neuro- genesis by applying modest depolarizing levels of extra-genesis (Monje et al., 2002; Palmer et al., 1997).”
• Hippocampal Avoidance During Whole-Brain Radiotherapy Plus Memantine for Patients With Brain Metastases: Phase III Trial NRG Oncology CC001. (2020, methodology): “To our knowledge, this trial provides the first definitive clinical evidence that the hippocampal neuroregenerative niche is important to pathophysiology of RT-induced cognitive decline and builds on extensive preclinical work and prior clinical studies.(9,10,12,13,27,28) This trial’s observation of”
• Adult neurogenesis: from precursors to network and physiology. (2005, background): “In this context, the role of the cerebral vasculature has gained importance as adult neurogenesis occurs within an “angiogenic niche,” and an alteration in the vascular microenvironment, or its ability to respond to changes in metabolic demands, may be responsible for a disruption in neurogenesis (3”
• Epigenetic Modulation of Seizure-Induced Neurogenesis and Cognitive Decline (2007, background): “, 2005), although the specificity of the above-mentioned ablation techniques (Monje et al., 2002) is subject to controversy within the field of adult neurogenesis (Dupret et al.”
• Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells (2006, background): “2001) as a means of killing dividing precursor cells are less selective than would be desired, with many structural and potentially functional side effects (Monje et al. 2002).”
• Neurogenesis in the adult brain: new strategies for central nervous system diseases. (2004, background): “In addition, adult neurogenesis occurs in microenvironments that consist of multiple, regionally specialized cell types, some of which may be glia (51, 53, 54, 156).”
• Experience dictates stem cell fate in the adult hippocampus. (2011, positive): “Exposure to X-irradiation blocks neurogenesis and disrupts the neurogenic niche (Monje et al., 2002; Santarelli et al., 2003), while exercise with environmental enrichment (EEE) potently stimulates neurogenesis (Doetsch and Hen, 2005; Dranovsky and Hen, 2006; Ming and Song, 2005; van Praag et al.”
• Immune Influence on Adult Neural Stem Cell Regulation and Function (2009, positive): “Rodent models showed that the effects of irradiation were surprisingly selective for neurogenesis (Monje et al., 2002).”
• Radiation-induced brain injury: A review (2012, background): “, 1996), decreased proliferation of the surviving NSC, and decreased NSC differentiation into neurons (Snyder et al., 2001; Monje et al., 2002; Mizumatsu et al., 2003).”
• Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory. (2009, methodology): “We used X-ray irradiation to inhibit neurogenesis in the subgranular zone of the DG (Monje et al., 2002; Santarelli et al., 2003) (see Figure S1 available online).”
• Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers (2017, background): “hippocampal neurogenesis in rats results in cognitive decline (Monje et al., 2002) and clinical evidence of cognitive changes in patients receiving radiation therapy and chemotherapy (Monje & Dietrich, 2012).”
• Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during whole-brain radiotherapy for brain metastases (RTOG 0933): a phase II multi-institutional trial. (2014, background): “Preclinical studies have demonstrated that relatively modest doses of radiation cause an early and significant decline in neurogenesis in the subgranular zone and that this loss in neurogenic capacity is associated with suppression of new memory formation and impaired recall.(3) In addition, recent ”
• Electroconvulsive seizure restores neurogenesis and hippocampus‐dependent fear memory after disruption by irradiation (2008, background): “Monje et al. (2002) suggest that precursors cease dividing due to intrinsic damage or lack of extrinsic mitogenic cues, including the disruption of the neurovascular relationship (Palmer et al., 2000) and increased inflammation (Ekdahl et al., 2003; Mizumatsu et al., 2003; Monje et al., 2003; Rola…”