Functional neurogenesis in the adult hippocampus

By H. van Praag, A. F. Schinder, B. Christie, N. Toni, T. Palmer, Fred H. Gage. 2002

2,983 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology

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Citations in the corpus

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “The rapid progress can be largely attributed to introducing BrdU (Kuhn et al., 1996) and retroviral (van Praag et al., 2002) methods for birth-dating, genetic marking, and phenotypic characterization by immunohistology, confocal and electron microscopy, and electrophysiology.”
Adult neurogenesis: from precursors to network and physiology. (2005, background): “However, a depression of synaptic currents is evoked in these cells following the paired-pulse stimulation of the perforant pathway, whereas a facilitation response is observed in mature cells, a discrepancy attributed to differences in presynaptic release properties (556).”
New neurons in the dentate gyrus are involved in the expression of enhanced long‐term memory following environmental enrichment (2005, background): “Within a few weeks newborn granule cells become functionally integrated into hippocampal circuitry (Hastings & Gould, 1999; Markakis & Gage, 1999) and develop physiological characteristics of mature granule cells (van Praag et al., 2002).”
In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus. (2007, result): “%) that we observed is comparable to results from BrdU-or retrovirus-mediated fate mapping of dividing cells in the hippocampus (Steiner et al., 2004; van Praag et al., 2002).”
Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. (2007, methodology): “Genetic Marking and Manipulation with Engineered Oncoretroviruses and Lentiviruses Engineered self-inactivating murine oncoretroviruses were used to express shRNAs and GFP (pUEG) or mCherry (pUEM) specifically in proliferating cells and their progeny (van Praag et al., 2002).”
Neurogenesis in the adult brain: new strategies for central nervous system diseases. (2004, background): “Within four weeks, they send axons to the CA3 region to form mossy fibers and project dendrites to the outer molecular layer (34, 35, 37, 38).”
Radiation-Induced Cognitive Impairments are Associated with Changes in Indicators of Hippocampal Neurogenesis (2004, background): “Ultimately, the newly born neurons become functionally integrated into the dentate gyrus and have passive membrane properties, action potentials and functional synaptic inputs (20).”
Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain (2008, methodology): “We further quantified the development of the adult-born boutons with several morphologic features that have been used in previous studies (16, 17) [see Methods; all morphologic data are summarized in supporting information (SI) Table S1].”