Notch signaling: from the outside in.

By J. Mumm, Raphael Kopan. Developmental Biology, 2000

1,034 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/be2c33d9ad4dbb070fc380b5853520a3da1766ba

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Citations in the corpus

Integration of TGF‐β/Smad and Jagged1/Notch signalling in epithelial‐to‐mesenchymal transition (2004, background): “…of the Delta, Serrate/Jagged, or Caenorhabditis elegans Lag-2 (DSL) family initiates proteolytic processing of Notch receptors mediated by accessory protein complexes and g-secretase activity, followed by nuclear translocation of the intracellular domain of Notch (NICD) (Mumm and Kopan, 2000).”
The ADAMs family of metalloproteases: multidomain proteins with multiple functions. (2003, background): “The Notch/Delta signaling system is involved in the development of the nervous system (Mumm and Kopan 2000).”
The role of notch in promoting glial and neural stem cell fates. (2002, background): “A great deal of research has been focused on understanding how the Notch signal is transmitted and regulated on the molecular level (Mumm & Kopan 2000, Weinmaster, 1997).”
Hypoxia requires notch signaling to maintain the undifferentiated cell state. (2005, background): “…Manner As the experiments described above implicated Notch signaling in mediating the effect of hypoxia on differentiation, we next wanted to investigate whether expression of Notch immediate downstream genes (Hes and Hey) (Greenwald, 1998; Mumm and Kopan, 2000) was altered by hypoxia.”
Notch signalling: a simple pathway becomes complex (2006, background): “Furthermore, Lunatic Fringe, a mammalian homologue of Fringe, potentiates Delta binding in in vitro studies and promotes Notch activity at the somite clefts, but behaves as a Notch inhibitor within the Delta-driven oscillatory somite clock in some specie”
Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging. (2010, background): “The canonical Notch signal links the transmembrane receptors to a nuclear CSL (RBP-J in mice) transcriptional complex (Mumm and Kopan, 2000).”
Liver regeneration (2007, background): “There are several members to this family of proteins and they compose a complex network mediating ligand–receptor interactions between cells, in tissues undergoing differentiation and proliferation related changes (Mumm and Kopan, 2000; Baron et al., 2002; Baron, 2003).”
The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex (2010, background): “Signaling of the Notch receptor is dependent on three types of proteolytic events (Mumm and Kopan, 2000).”
ADAMs: key components in EGFR signalling and development (2005, background): “Several other aspects of ADAMs research — such as their role in cell–cell interactions, in the activation of the cell-surface receptor Notch, in axon guidance, in asthma, or as α-secretases in Alzheimer's disease — have not been included, because they have been recently reviewed elsewher”