Notch signalling: a simple pathway becomes complex

By S. Bray. Nature reviews. Molecular cell biology, 2006

2,725 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b4e120667bcf0cc243110770d012a2105672ba61

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. M. Ilagan
2. Duojia Pan
3. R. Adams
4. A. Capobianco
5. Raphael Kopan
6. M. Matzuk
7. M. Fortini
8. Kelly L. Weaver

Citations in the corpus

• Hippo signaling in organ size control. (2007, background): “Hpo signaling in other developmental processes A recurring theme in developmental biology is the use of a single signaling cascade in multiple, and sometimes seemingly unrelated, biological processes (e.g., see Bray 2006).”
• Notch signaling: the core pathway and its posttranslational regulation. (2009, background): “…highly regulated and the net result is intramembrane proteolysis of the intact, membrane-bound Notch receptor and consequent release of a soluble fragment consisting of the entire intracellular domain, termed Notch intracellular domain (NICD; Figure 1; reviewed in Bray, 2006; Gordon et al., 2008).”
• The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis. (2009, neutral): “However, the regulation of endothelial cell (EC) sprouting and proliferation also involves intrinsic signaling interactions between ECs that are, for example, mediated by the Notch pathway (Bray, 2006; Roca and Adams, 2007).”
• The mammalian ovary from genesis to revelation. (2009, background): “The NICD translocates to the nucleus and interacts with the DNA-binding CSL [CBF1, Su(H), and Lag-1] transcription factor and its coactivator, Mastermind, to promote transcription (147).”
• iNOS promotes CD24+CD133+ liver cancer stem cell phenotype through a TACE/ADAM17-dependent Notch signaling pathway (2018, background): “Notch signaling promotes the progression of solid cancers (22) by driving angiogenesis (23) and maintaining a population of undifferentiated CSCs. Notch signaling is triggered when the Notch receptor is cleaved/activated at site 2 (S2; Val1711) (24) by ADAM (a disintegrin and metalloprotease) 10 or ”
• The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism (2009, background): “…although the CSL protein RBPjκ can form complexes with many ubiquitous corepressor proteins, such as CIR, FLH1C/KyoT2, and NCoR/SMRT (reviewed in Bray, 2006), it is SHARP/MINT/SPEN that has emerged as the critical repressor of Notch target genes in vivo (Oswald et al., 2005; Tsuji et al.,…”
• Notch–RBP-J signaling controls the homeostasis of CD8− dendritic cells in the spleen (2007, background): “The Notch signaling pathway is an evolutionarily conserved mechanism regulating the development of multiple cells and tissues (13).”
• Engineering T cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors (2016, neutral): “When it engages the cognate antigen, the synNotch receptor undergoes induced transmembrane cleavage, akin to native Notch activation (Bray, 2006; Selkoe and Kopan, 2003), thereby releasing the intracellular transcriptional domain to enter the nucleus and activate expression of target genes regulated”
• A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma (2018, background): “The Notch pathway is involved in the development, differentiation, growth and fate of multiple different cell types (Bray, 2006), and has a fairly limited set of known target genes, including transcriptional regulators Hes (hairy/enhancer of split) and Hey (subfamily of Hes) (Borggrefe and Oswald, 2”
• Hypoxia-inducible factors in stem cells and cancer (2009, neutral): “Signalling is initiated when the Jagged or Delta family of ligands binds a Notch receptor, triggering a two-step receptor proteolysis event [59].”
• Molecular regulation of angiogenesis and lymphangiogenesis (2007, background): “This complex allows the expression of basic helix–loop–helix (bHLH) proteins of the hairy/enhancer-of-split-related transcription factor family — Hey2 and Her in zebrafish, and Hey and Hes in mammals — which, in turn, control the expression of other downstream target gene”