The role of notch in promoting glial and neural stem cell fates.

By N. Gaiano, G. Fishell. Annual Review of Neuroscience, 2002

628 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8e2eb73fbe722f5f2b0ab9d9b2487aeb2f8ec876

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In Developmental Neuroscience

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Citations in the corpus

[P2.15]: Oscillations in notch signaling regulate maintenance of neural progenitors (2008, positive): “It has been shown that Notch signaling plays an important role in the maintenance of neural progenitors (Artavanis-Tsakonas et al., 1999; Gaiano and Fishell, 2002; Honjo, 1996; Selkoe and Kopan, 2003).”
Neurodegenerative disease and adult neurogenesis (2011, background): “Huntingtin is a cytoplasmatic protein that has a role in vesicular trafficking but also functions in transcriptional regulation, and nucleo-cytoplasmatic shuttling and synaptic functions are proposed (Caviston & Holzbaur, 2009).”
Brain micro-ecologies: neural stem cell niches in the adult mammalian brain (2008, background): “Notch is activated upon binding Delta or Jagged, both membrane ligands, which causes cleavage of the intracellular tail of Notch and its translocation to the nucleus (reviewed in Gaiano & Fishell 2002).”
Astrocytes and disease: a neurodevelopmental perspective. (2012, background): “One example of this is N-CoR, a nuclear receptor corepressor for multiple transcription factors, including the notch effector RBP-J (CBF-1) (Gaiano and Fishell 2002).”
Notch signaling in the mammalian central nervous system: insights from mouse mutants (2005, background): “dtd" [ ]> The role of the Notch pathway during animal neural development is best understood in fruit flies, where Notch has been shown to inhibit differentiation by lateral signaling and regulate cell fate through inductive interaction”
Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. (2006, background): “Notch is known to promote the survival and proliferation of nonneoplastic neural stem cells and to inhibit their differentiation (36, 37).”
Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation (2004, background): “The basic helix-loop-helix genes Hes1 and Hes5 are essential effectors for Notch signalling, which regulates the maintenance of undifferentiated cells (Artavanis-Tsakonas et al., 1999; Gaiano and Fishell, 2002; Hitoshi et al., 2002; Honjo, 1996; Kageyama and Nakanishi, 1997; Selkoe and Kopan, 2003).”
The Glial Nature of Embryonic and Adult Neural Stem Cells (2009, background): “Notch activation maintains cells in a proliferative state (Dorsky et al. 1997, Gaiano & Fishell 2002, Silva et al. 2003, Zhang et al. 2008) and is critical to maintain RG cell identity and self-renewal (Gaiano et al. 2000).”