Butyrate Enhances Intestinal Epithelial Barrier Function via Up-Regulation of Tight Junction Protein Claudin-1 Transcription

By Hong-bo Wang, Peng-yuan Wang, Xin Wang, Y. Wan, Yucun Liu. Digestive Diseases and Sciences, 2012

742 citations recorded by the source corpus.

Subfields: Gastroenterology, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/845fccf48a216b5eb0c90ebaf7d2e6376d4e5ae1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Gastroenterology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. C. Stanton
5. R. Stilling
6. P. Kennedy
7. J. Foster

In Molecular Biology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. C. Stanton
5. R. Stilling
6. M. van de Wouw
7. E. Canfora
8. Ellen E. Blaak

Citations in the corpus

• Short chain fatty acids in human gut and metabolic health. (2020, positive): “In monolayers of differentiated intestinal epithelial cells (cdx2-IEC), butyrate contributed to the intestinal barrier function by increasing the expression of the TJ protein claudin-1 (Wang et al. , 2012).”
• Intestinal permeability – a new target for disease prevention and therapy (2014, background): “It has been shown that butyrate decreases bacterial translocation in cells models [154] and modifies the expression of the tight junction proteins claudin-1 and claudin-2 in favor of a barrier preservation [99,155].”
• The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis? (2016, background): “Thus, butyrate and other SCFAs have been shown to strengthen the integrity of the epithelial barrier by upregulating and reorganization of tight junction proteins that connect epithelial cells via various seemingly independent mechanisms including HDAC inhibition as well as activation of the AMP-act”
• Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism (2016, background): “Of the SCFA produced in the colon, butyrate appears to be the most important regulator of TJP and has been shown to enhance intestinal barrier function through increased expression of claudin-1 and Zonula Occludens-1 (ZO-1) and occludin redistribution; proteins which are critical components of the t”
• Butyrate: A Double-Edged Sword for Health? (2018, neutral): “On the basis of the physiologic concentration in mammalian gastrointestinal tract, the recommended concentration of butyrate used in in vitro models is currently 0–8 mM (80).”
• SCFA: mechanisms and functional importance in the gut (2020, background): “Moreover, butyrate reduces epithelial permeability by the regulation of IL-10 receptor, occludin, zonulin and claudins, reinforcing the tight junctions and the transepithelial resistance in vitro((135,136)).”
• Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases (2019, background): “As a result, butyrate maintains and/or increases transepithelial electrical resistance (TEER) in human colonic Caco-2 and T84 cells (77–80), rat small intestine cdx2-IEC cells (81) and small intestine porcine IPEC-J2 cells even when exposed to inflammatory conditions (82).”