Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization

By E. Nemeth, Marie S. Tuttle, J. Powelson, Michael B. Vaughn, A. Donovan, D. Ward, T. Ganz, J. Kaplan. Science, 2004

4,434 citations recorded by the source corpus.

Subfields: Genetics, Hematology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/be142fdd8ce83e8f714541133fe8cf628d8d7b12

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. T. Ganz
2. E. Nemeth
3. V. Haase
4. A. Pietrangelo
5. C. Wood
6. C. Brauner
7. A. Farrell
8. D. Richardson

In Hematology

1. T. Ganz
2. E. Nemeth
3. V. Haase
4. A. Pietrangelo
5. C. Wood
6. C. Brauner
7. A. Farrell
8. D. Richardson

In Nutrition and Dietetics

1. T. Ganz
2. E. Nemeth
3. C. Wood
4. C. Brauner
5. A. Farrell
6. Taiho Kambe
7. Tracey Rouault
8. Ayako Hashimoto

Citations in the corpus

• The Role of Hepcidin in Iron Metabolism (2009, background): “Posttranslational control of ferroportin levels by its ligand hepcidin is the major mode of ferroportin regulation. The binding of hepcidin to ferroportin triggers the internalization and degradation of the receptor-ligand complex [”
• Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. (2008, background): “Loss of ferroportin activity prevents mobilization of iron to the bloodstream from intracellular stores in enterocytes, macrophages and hepatocyte”
• Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). (2007, background): “It has recently been shown ex vivo that hepcidin binds ferroportin, the only known iron exporter, thereby trapping iron within enterocytes and macrophages (1).”
• Homeostasis, Inflammation, and Disease Susceptibility (2015, neutral): “The examples are chosen to illustrate the point. dietary iron uptake and prevent iron overload (Nemeth et al., 2004).”
• Iron metabolism and iron disorders revisited in the hepcidin era (2020, neutral): “The protein is ultimately controlled at the post-translational level by hepcidin.(13)”
• The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. (2005, background): “Indeed, hepcidin can exert control of ferroportin by modulating protein levels (Nemeth et al., 2004).”
• The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism. (2015, background): “This is in contrast to iron metabolism, where a short peptide hormone hepcidin plays a critical role in systemic iron homeostasis (296).”
• A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. (2005, background): “Additional factors/ conditions, including IL-6, c/EBP a , iron, hypoxia, and inflammation, also regulate hepcidin expression (Courselaud et al., 2002; Nemeth et al., 2004a).”