The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis.

By A. Donovan, C. Lima, J. Pinkus, G. Pinkus, Leonard I. Zon, S. Robine, N. Andrews. Cell Metabolism, 2005

1,222 citations recorded by the source corpus.

Subfields: Genetics, Hematology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/d1bcb79f5b952f63dc39933ff4efd5c2b02a84de

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In Genetics

1. E. Nemeth
2. T. Ganz

In Hematology

1. E. Nemeth
2. T. Ganz
3. M. Valko
4. D. Tang
5. K. Jomová

In Nutrition and Dietetics

1. T. Ganz
2. K. Jomová
3. E. Nemeth
4. D. Tang
5. R. Kang
6. M. Kerins
7. M. Valko
8. Aikseng Ooi

Citations in the corpus

• Advances in metal-induced oxidative stress and human disease. (2011, background): “ormation of hepcidin leading tomore ironbeing absorbed from the ntestine and effluxed in the circulation (Donovan et al., 2005).”
• The Roles of NRF2 in Modulating Cellular Iron Homeostasis (2017, background): “FPN1 exports iron from iron-absorbing enterocytes of the intestinal lining into the bloodstream, thus adjusting the amount of dietary iron entering circulation (27).”
• The Role of Hepcidin in Iron Metabolism (2009, positive): “Hepcidin also appears to block, at least partially, the export of stored iron from hepatocytes as indicated by hepatic iron accumulation in mice carrying hepcidin-overproducing tumors. 2 Fig. 2. Hepcidin-ferroportin (Fpn) interaction determines the flow of iron into plasma. Hepcidin concentratio”
• Iron Metabolism in Ferroptosis (2020, background): “The global knockout of SLC40A1 in mice leads to embryonic lethality, while the selective knockout of SLC40A1 in postnatal intestine results in severe iron deficiency (Donovan et al., 2005).”
• Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies (2024, background): “90 Consistently, deletion of TF, TFR1, SLC11A2 and NCOA1, and overexpression of FTH1, FTL and SLC40A1 suppresses ferroptosis by decreasing the LIP.”
• An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation (2020, background): “export from the cytosol to the extracellular milieu [112].”
• Systemic iron homeostasis. (2013, background): “Therefore, the partitioning of iron between duodenal enterocytes (the mucosa) and the plasma effectively determines the body iron content (60).”