Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism.

By P. Yu, C. Hong, Chetana Sachidanandan, Jodie L Babitt, D. Y. Deng, S. Hoyng, Herbert Y. Lin, K. Bloch, Randall T. Peterson. Nature Chemical Biology, 2008

1,065 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Obstetrics and Gynecology

View Paper: https://www.semanticscholar.org/paper/47fee04a384edb3a0756cd41eb9b5eb358d587f3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. T. Ganz

In Molecular Biology

1. T. Ganz
2. F. Canonne-Hergaux
3. Delphine Meynard
4. H. Coppin
5. M. Roth
6. Léon Kautz
7. Valérie Darnaud
8. T. Peel

Citations in the corpus

• Lack of the bone morphogenetic protein BMP6 induces massive iron overload (2009, background): “11 ), and chemical inhibition of BMP signal transduction in a human hepatoma cell line blocks the induction of hepcidin expression not only by BMPs but also by IL-6 (ref”
• BMP-6 is a key endogenous regulator of hepcidin expression and iron metabolism (2009, positive): “We have also shown that iron administration in vivo increases hepatic BMP signalin”
• The Role of Hepcidin in Iron Metabolism (2009, positive): “In practice, however, many patients are first diagnosed with advanced iron overload. In that scenario, hepcidin agonists may be useful as adjuncts to therapeutic phlebotomy, where they would act to redistribute iron to macrophages and away from parenchymal cells, block further iron absorption and ev”