A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression.

By Ruihong Wang, Cuiling Li, Xiaoling Xu, Yin Zheng, C. Xiao, P. Zerfas, S. Cooperman, M. Eckhaus, Tracey Rouault, L. Mishra and 1 more. Cell Metabolism, 2005

650 citations recorded by the source corpus.

Subfields: Genetics, Hematology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/84f797e21ef33a8881154d16c13c497c899e525a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. A. Pietrangelo
2. T. Ganz
3. Randall T. Peterson
4. J. Massagué
5. R. DePinho
6. D. Hanahan
7. V. Haase
8. E. Nemeth

In Hematology

1. A. Pietrangelo
2. T. Ganz
3. J. Massagué
4. E. Nemeth
5. V. Haase

In Nutrition and Dietetics

1. T. Ganz

Citations in the corpus

• The changing faces of glutathione, a cellular protagonist. (2003, background): “Reportedly, cancer may hijack cytokine systems (e.g., SMAD4) via mutation to collect iron for proliferation (Wang et al., 2005).”
• TGFβ in Cancer (2008, background): “Indeed, ablation of SMAD4 in the mammary gland, liver, or pancreas of mice does not derail the development of the targeted organ even though the disruption of TGFβ family receptors does (Bardeesy et al., 2006; Li et al., 2003; Wang et al., 2005a).”
• BMP-6 is a key endogenous regulator of hepcidin expression and iron metabolism (2009, positive): “Recently, a role for the BMP signaling pathway in hepcidin regulation was discovere”
• Lack of the bone morphogenetic protein BMP6 induces massive iron overload (2009, background): “Although many BMP ligands, including BMP2, BMP4 and BMP9, can positively regulate hepcidin expression in vitro”
• High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin (2007, background): “Recently, transforming growth factor-β (TGFB) superfamily members have been identified as regulators of hepcidin expressio”
• Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. (2008, background): “Mice conditionally deficient in SMAD4 fail to induce hepcidin following iron or interleukin 6 (IL-6) challeng”
• Systemic iron homeostasis. (2013, background): “The BMP receptor and its canonical SMAD pathway are at the core of the hepcidin-regulating complex as indicated by the strong induction of hepcidin by multiple BMPs (10, 11), the presence of several functional BMP-response elements in the hepcidin promoter (31, 249, 254), and the profound effect of ”
• Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. (2006, background): “The dispensability of Smad4 for pancreatic organogenesis mirrors what has been observed in the liver and breast (Li et al. 2003; Wang et al. 2005); in contrast, Smad4 is required during early development to pattern derivatives of the anterior primitive streak and for formation of extraembryonic…”