The Role of Hepcidin in Iron Metabolism

By E. Nemeth, T. Ganz. Acta Haematologica, 2009

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TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord. (2014, positive): “For accumulation to occur, the iron exporter ferroportin (Fpn) needs to be removed from the cell membrane, which requires hepcidin-mediated 1112 Neuron 83, 1098–1116, September 3, 2014 ª2014 Elsevier Inc. internalization of Fpn and its degradation (Nemeth and Ganz, 2009).”
Homeostasis and toxicology of essential metals (2012, background): “The hepcidin gene encodes an 84–amino acid prepropeptide, which is cleaved to form a 20–26 amino acid active peptide that is characterized by eight cysteines that form disulfide bridges, creating a hairpin structure (Nemeth and Ganz, 2009).”
Diagnosis and Management of Hemochromatosis: 2011 Practice Guideline by the American Association for the Study of Liver Diseases (2011, background): “Hepcidin is a 25–amino acid peptide that influences systemic iron status.(25) It is considered to be the principal iron-regulatory hormone.”