Mesenchymal Stem Cells Secrete Immunologically Active Exosomes

By Bin Zhang, Yijun Yin, R. C. Lai, S. S. Tan, A. Choo, S. Lim. Stem Cells and Development, 2014

602 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5540f1036898d4c2fc802ffd449bfe7b0a4683a1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. C. Gregory
2. Jeffrey L Spees
3. R. Lee

In Molecular Biology

1. C. Gregory
2. S. Lim
3. Jeffrey L Spees
4. R. C. Lai
5. R. Lee

Citations in the corpus

• Mechanisms of mesenchymal stem/stromal cell function (2016, background): “In addition, exosomal transfer from MSCs is reported to reduce inflammation and to increase cell proliferation during tissue repair [162, 165, 166].”
• MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity. (2018, result): “This is consistent with the previously reported immunomodulatory property of MSC exosomes [55] that MSC exosomes could induce expression of antiinflammatory IL-10 and TGF-b1 and attenuate expression of proinflammatory IL-1b, IL-6, TNF-a and IL-12P40 in THP-1 monocytes.”