Antioxidants prevent health-promoting effects of physical exercise in humans

By Michael Ristow, K. Zarse, A. Oberbach, N. Klöting, M. Birringer, M. Kiehntopf, M. Stumvoll, C. Kahn, M. Blüher. Proceedings of the National Academy of Sciences of the United States of America, 2009

1,557 citations recorded by the source corpus.

Subfields: Nutrition and Dietetics, Physiology, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/bdcf75b86dd87bd075afe9b057a08900a1178359

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In Nutrition and Dietetics

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Michael Ristow

Citations in the corpus

Vitamins C and E: Beneficial effects from a mechanistic perspective (2011, neutral): “stress insult, for example, physical exercise [81].”
Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders (2010, neutral): “Importantly, recent ﬁnding indicates that supplementation with antioxidants may preclude these health-promoting effects of exercise in humans (372).”
The Mitochondrial Basis of Aging (2016, background): “These negative effects of redox scavengers are reminiscent of similar observations in humans where, for instance, the beneficial effects of exercise appear to be abrogated by antioxidant supplementation (Ristow et al., 2009).”
Mitochondrial function as a therapeutic target in heart failure (2016, neutral): “Consistent with the ROS hormesis concept, several studies have noted that administration of high doses of ROS scavengers can abolish the beneficial effects of exercise 112,113 , including humans taking oral vitamin C or E supplements 114 .”
Exercise is the real polypill. (2013, background): “Interestingly, despite its popularity among westerners for its hypothetical anti-disease/rejuvenating effects, antioxidant supplementation does not mimic, and in fact can reverse, beneficial exercise adaptations (127, 148, 149, 226, 404).”
The role of mitochondria in aging. (2013, neutral): “In this respect, it is interesting to note that exercise-induced increase of ROS production and oxidative stress in human skeletal muscle ameliorate insulin resistance and improve glucose metabolism (99), thus suggesting that increased ROS levels might not be the sole determinant of age-related func”
Role of ROS and RNS Sources in Physiological and Pathological Conditions (2016, background): “Moreover, notwithstanding conflicting results exist in literature [349], it was reported that antioxidant supplementation attenuates the PGC-1α expression increase due to training [316–318, 350–352].”
Extending life span by increasing oxidative stress. (2011, background): “Moreover, health-promoting effects were demonstrated to be reduced if subjects exposed to physical activity were cotreated with antioxidant supplements [186,243].”
ROS Function in Redox Signaling and Oxidative Stress (2014, background): “To date, physical exercise is one strategy that increases ROS, resulting in activation of beneficial pathways that diminish cancer, diabetes, and ageing [150].”
ESPEN guidelines on nutrition in cancer patients. (2017, background): “, in a randomized design, supplied healthy subjects with vitamin C (1000 mg/day) and vitamin E (400 IU/day) or placebo during a 4-week physical exercise training program and observed an abrogation by the vitamins of the exercise-induced improvement in insulin resistance [142].”
Mechanisms and Mitochondrial Redox Signaling in Photobiomodulation (2018, background): “A study (129) reported that administration of vitamins”
How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis). (2010, background): “Notably, supplementation with ROS-reducing antioxidants inhibits (Gomez-Cabrera et al., 2008; Ristow et al., 2009) the health-promoting effects (Higuchi et al., 1985; Lindsted et al., 1991; Manini et al., 2006; Warburton et al., 2006; Lanza et al., 2008) of physical exercise .”
Mitochondrial ROS signaling in organismal homeostasis. (2015, background): “Ristow and colleagues showed that suppressing ROS generation during aerobic exercise (likely, in large part, mtROS) diminishes beneficial outcomes on many exercise-related parameters (Ristow et al., 2009).”