Mechanisms and Mitochondrial Redox Signaling in Photobiomodulation

By Michael R Hamblin. Photochemistry and Photobiology, 2018

699 citations recorded by the source corpus.

Photobiomodulation (PBM) involves the use of red or near‐infrared light at low power densities to produce a beneficial effect on cells or tissues. PBM therapy is used to reduce pain, inflammation, edema, and to regenerate damaged tissues such as wounds, bones, and tendons. The primary site of light absorption in mammalian cells has been identified as the mitochondria and, more specifically, cytochrome c oxidase (CCO). It is hypothesized that inhibitory nitric oxide can be dissociated from CCO, thus restoring electron transport and increasing mitochondrial membrane potential. Another mechanism involves activation of light or heat‐gated ion channels. This review will cover the redox signaling that occurs in PBM and examine the difference between healthy and stressed cells, where PBM can have apparently opposite effects. PBM has a marked effect on stem cells, and this is proposed to operate via mitochondrial redox signaling. PBM can act as a preconditioning regimen and can interact with exercise on muscles.

Subfields: Insect Science, Pharmacology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/2f263eb4c58932660248c12f723b3bf09cad620d

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Citations in the corpus

• The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies (2021, background): “Activation of the UCP2 protein occurs by an increase in ROS emitted [69], thus providing an important mechanism for limiting the production of ROS, such as superoxide anion •O2−, Figure 18.”