A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans

By Robert J. Johnston Jr., O. Hobert. Nature, 2003

781 citations recorded by the source corpus.

Subfields: Aging, Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems

View Paper: https://www.semanticscholar.org/paper/bdad4f04c7b1e82a4c71627dc12eccdb4fb677f7

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Citations in the corpus

Human MicroRNA Targets (2004, background): “However, confirmed miRNA:mRNA target pairs can have mismatches in this region (Moss et al. 1997; Johnston and Hobert 2003).”
Identification of hundreds of conserved and nonconserved human microRNAs (2005, background): “dtd" [ ]> MicroRNAs are noncoding RNAs of ∼22 nucleotides that suppress translation of target genes by binding to their mRNA and thus have a central role in gene regulation in health and diseas”
MicroRNA targeting specificity in mammals: determinants beyond seed pairing. (2007, background): “…interactions and the Drosophila miR-4:Bearded interactions all involve dual conserved 8mer sites with short intersite spacing ([Lee et al., 1993; Wightman et al., 1993; Johnston and Hobert, 2003; Lai et al., 2005]; see http://www.targetscan.org for minor refinements to C. elegans site annotations).”
Principles of MicroRNA–Target Recognition (2005, background): “[18], that bantam miRNA controls tissue growth [19], and that bantam and miR-14 control apoptosis [19,20].”
Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. (2007, positive): “In some cases, they function to ‘‘fine-tune’’ physiologic events, but in others they function as molecular ‘‘switches’’ (Brennecke et al., 2003; Johnston and Hobert, 2003; Kwon et al., 2005; Lee et al., 1993; Moss et al., 1997; Reinhart et al., 2000; Sokol and Ambros, 2005; Wightman et al., 1993).…”
MicroRNA functions in animal development and human disease (2005, background): “Function of animal microRNAs in vivo Process microRNA Targets Function Evidence Key citations C. elegans Developmental timing lin-4 microRNA lin-14, lin-28 Stem cell differentaition LOF Lee et al., 1993; Wightman et al., 1993 Developmental timing let-7 microRNA lin-41, hbl-1, Stem cell differentaiti”
Revisiting the principles of microRNA target recognition and mode of action (2009, background): “pl?acc=MI0000801">lsy-6 regulates its target cog-1 through seed sites, an elegant use of in vivo lsy-6 sensors has shown that GU wobble pairs in the seed region are often tolerated, and that the occurrence of seed matches was in fact a poor predictor of lsy-6-mediated repressio”
Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation (2014, background): “To date, 24521 microRNAs have been discovered and there are certainly more to come.”
Perspective: machines for RNAi. (2005, background): “…Mourelatos et al. 2002; Reinhart and Bartel 2002; Brennecke and Cohen 2003; Brennecke et al. 2003; Chen 2004; Chen et al. 2004; Dostie et al. 2003; Johnston and Hobert 2003; Lim et al. 2003a,b; Palatnik et al. 2003; Chang et al. 2004). miRNAs are cousins of siRNAs: They are endogenous small RNA…”
microRNAs as oncogenes and tumor suppressors. (2007, background): “Subsequent studies determined that let-7 is highly conserved in animals from worm to human (Pasquinelli et al., 2000), and its expression is dependent on developmental timing (Johnson et al., 2003; Johnston and Hobert, 2003; Miska et al., 2004; Thomson et al., 2004).”
miRWalk - Database: Prediction of possible miRNA binding sites by "walking" the genes of three genomes (2011, background): “In the past couple of years, research groups demonstrated the involvement of miRNAs in complicated biological processes/pathways, including the control of developmental timing, haematopoietic cell differentiation, apoptosis, cell proliferation, organ development [10,11,46,47], as well as cancerogene”