P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury

By M. Tsuda, Yukari Shigemoto-Mogami, S. Koizumi, Akito Mizokoshi, S. Kohsaka, Michael W. Salter, Kazuhide Inoue. Nature, 2003

1,499 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Physiology

View Paper: https://www.semanticscholar.org/paper/bd9cb9bec1c495c916c9434ef821a601c4672d1e

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In Cellular and Molecular Neuroscience

In Physiology

Citations in the corpus

Purinergic signalling and disorders of the central nervous system (2008, background): “P2X receptor activation in the spinal cord might also elicit allodynia, with P2X 4 receptor upregulation in spinal cord microglia having a crucial rol”
Deconstructing the Neuropathic Pain Phenotype to Reveal Neural Mechanisms (2012, neutral): “In addition, substantial microglial activation is generated in the dorsal horn of the spinal cord in close vicinity of the central terminals of injured primary sensory neurons (Beggs and Salter, 2010; Tsuda et al., 2003).”
Activated Microglia Contribute to the Maintenance of Chronic Pain after Spinal Cord Injury (2006, background): “, 2002), and glutamate (Sluka and Westlund, 1993) are released in high amounts during central sensitization and participate in its induction and might activate microglia (Giulian et al., 1996; Svensson et al., 2003; Tsuda et al., 2003), so that the sensitization of dorsal horn neurons may also stimu”
Pathophysiology and Therapeutic Potential of Purinergic Signaling (2006, background): “P2X4 receptors, induced in spinal microglia, gate tactile allodynia after nerve injury (Tsuda et al., 2003) (see”
Live imaging of neuronal degradation by microglia reveals a role for v0-ATPase a1 in phagosomal fusion in vivo. (2008, neutral): “recent work has identified the P2Y12 purinergic receptor as the trigger of microglial chemotaxis and phagocytosis in response to neuronal injury in the brain (Koizumi et al., 2007; Tsuda et al., 2003).”
ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model (2005, background): “These data reinforce the hypothesis that microglia have a role in the pathogenesis of neuropathic pain (Abbadie et al., 2003; Ji and Strichartz, 2004; Jin et al., 2003; Raghavendra et al., 2003; Tsuda et al., 2003).”
p38 MAPK, microglial signaling, and neuropathic pain (2007, background): “Fortunately, nerve injury up regulates the ATP receptor P2X4 and the chemokine receptor CX3CR1 specifically in spinal microglia, and blocking these receptors results in decreased neuropathic pain [24-26].”
Models and mechanisms of hyperalgesia and allodynia. (2009, background): “Blockade of spinal P2X1–4 receptors by intrathecal injections of 2 ,3 -O-(2,4,6-trinitrophenyl)adenosine 5-triphosphate (TNP-ATP) temporarily reverses tactile hyperalgesia 7 days after spinal nerve ligation (522).”