Deconstructing the Neuropathic Pain Phenotype to Reveal Neural Mechanisms

By Christian A. von Hehn, R. Baron, Clifford J. Woolf. Neuron, 2012

782 citations recorded by the source corpus.

After nerve injury maladaptive changes can occur in injured sensory neurons and along the entire nociceptive pathway within the CNS, which may lead to spontaneous pain or pain hypersensitivity. The resulting neuropathic pain syndromes present as a complex combination of negative and positive symptoms, which vary enormously from individual to individual. This variation depends on a diversity of underlying pathophysiological changes resulting from the convergence of etiological, genotypic and environmental factors. The pain phenotype can serve therefore, as a window on underlying pathophysiological neural mechanisms, and as a guide for developing personalized pain medicine.

Subfields: Cognitive Neuroscience, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/5c6a0ad87cd97cca1a6bb9dd85bf01ae78faf59a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. J. Wolffsohn
2. F. Stapleton
3. C. Belmonte
4. J. Nichols
5. S. Cox
6. J. Brock
7. C. Begley
8. P. Hamrah

Citations in the corpus

• TFOS DEWS II pain and sensation report (2017, positive): “Hypersensitivity of CNS neurons is thought to derive from a combination of increased excitatory synaptic drive and/or loss of inhibitory controls [5,338].”
• Nociceptor Sensory Neuron-Immune Interactions in Pain and Inflammation (2016, neutral): “9, which induce moreready action potential generation and pain sensitivity [105].”