Pathophysiology and Therapeutic Potential of Purinergic Signaling

By G. Burnstock. Pharmacological Reviews, 2006

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Contribution of the region Glu181 to Val200 of the extracellular loop of the human P2X1 receptor to agonist binding and gating revealed using cysteine scanning mutagenesis1 (2009, neutral): “P2X receptors are involved in a range of processes including neuronal excitability, pain sensation and bone formation (Burnstock 2006).”
Immune cell regulation by autocrine purinergic signalling (2011, background): “, the pharmacological and structural properties of the different purinergic receptor”
Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells (2007, background): “Extracellular ATP has recently gained attention as a mediator of intercellular communication, through the activation of purinergic receptors (P2XR and P2YR”
International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy (2006, background): “…of P2Y receptors in pathological conditions and in the therapeutic potential of P2Y receptor-related compounds (see also reviews by Burnstock and Williams, 2000; Boeynaems et al., 2001, 2005a,b; Yerxa, 2001; Burnstock, 2002, 2006; Jacobson et al., 2002; Ralevic and Burnstock, 2003; Gachet, 2005).”