Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

By Elisa Gomez Perdiguero, Kay Klapproth, Christian Schulz, Katrin Busch, Emanuele Azzoni, L. Crozet, Hannah Garner, Céline Trouillet, M. D. Bruijn, F. Geissmann and 1 more. Nature, 2014

2,091 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology

View Paper: https://www.semanticscholar.org/paper/bd9a55cefa5c6cab7f290103eaa5dc2954286f71

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Florent Ginhoux
2. J. Joyce
3. C. Garlanda

In Immunology

1. M. Guilliams
2. P. Murray
3. Florent Ginhoux
4. C. Garlanda
5. Marc Beyer
6. D. Brenner
7. J. Joyce
8. Joachim L. Schultze

Citations in the corpus

• Macrophage Polarization. (2017, background): “In the gut, macrophage turnover is rapid (days to weeks), whereas in the lungs, months to years are needed to replace the embryonic-derived alveolar macrophages (51, 53, 55, 56).”
• Tissue-Resident Macrophage Ontogeny and Homeostasis. (2016, methodology): “Given that, in adulthood, monocytes do not contribute to Kupffer cell (Gomez Perdiguero et al., 2015; Hoeffel et al., 2015; Schulz et al., 2012; Yona et al., 2013) or arterial macrophage (Ensan et al., 2016) populations, it appears that these tissues are somehow only temporarily ‘‘open’’ at birth bu”
• Sexual Dimorphism in Innate Immunity (2019, positive): “It has recently been shown that in the mouse, macrophage progenitors colonize peripheral tissues during embryogenesis and differentiate into tissue resident macrophages (Kupffer cells in liver, microglia in brain, Langerhans cells in the skin, and alveolar macrophages in lung), which will self-maint”
• Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms (2015, background): “However, it is shown that the resident tissue macrophages have heterogeneous progeny [187, 188].”
• Fundamental properties of unperturbed haematopoiesis from stem cells in vivo (2015, neutral): “8, 4) day (21), bCMP 5 4 (21, 4) day(21), bCLP 5 3 (0.”
• The microenvironmental landscape of brain tumors (2017, background): “Therefore, the maintenance of microglia in the normal adult brain is thought to occur through prolonged cellular longevity and local proliferation (Ajami et al., 2007; Elmore et al., 2014; Gomez Perdiguero et al., 2015).”
• Specification of tissue-resident macrophages during organogenesis (2016, methodology): “Shortlived OH-TAM allows transient nuclear translocation of the estrogen receptor–Cre recombinase fusion protein (MeriCreMer) in cells expressing the Csfr1MeriCreMer transgene and deletion of a floxed stop cassette (LSL) in the Rosa26LSL-YFP allele, resulting in stable yellow fluorescent protein (YF”