Sexual Dimorphism in Innate Immunity

By S. Jaillon, K. Berthenet, C. Garlanda. Clinical reviews in allergy and immunology, 2019

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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020, background): “21 Additionally, about half of patients infected by 2019nCoV had chronic underlying diseases, mainly cardiovascular and cerebrovascular diseases and diabetes; this is similar to MERSCoV.”
COVID‐19 patients' clinical characteristics, discharge rate, and fatality rate of meta‐analysis (2020, background): “The reduced susceptibility of females to viral infections could be attributed to the protection from X chromosome and sex hormones, which play an essential role in innate and adaptive immunity.(24) But men should pay more attention to protective measures.”
Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis (2020, background): “It is customary to think women are less likely to affect many bacteria and viruses than men, partly because of their more robust innate and adaptive immune responses 13 .”