Fundamental properties of unperturbed haematopoiesis from stem cells in vivo

By Katrin Busch, Kay Klapproth, Melania Barile, M. Flossdorf, T. Holland-Letz, Susan M. Schlenner, M. Reth, T. Höfer, H. Rodewald. Nature, 2015

659 citations recorded by the source corpus.

Subfields: Hematology, Immunology

View Paper: https://www.semanticscholar.org/paper/dd132570697e863928c5651d3bc84834904fe0d7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hematology

1. J. Dick
2. Benjamin L. Ebert
3. A. Wagers
4. E. Laurenti
5. E. Passegué
6. R. Majeti
7. Irving L. Weissman

In Immunology

1. A. Mildner
2. Aviv Regev
3. Howard Y. Chang
4. J. Dick
5. S. Yona
6. A. Wagers
7. M. Guilliams
8. R. Majeti

Citations in the corpus

• Developmental and Functional Heterogeneity of Monocytes. (2018, background): “In this model, a fraction of active haematopoietic stem cells (HSC (Busch et al., 2015)) have the ability to self-renew to generate a heterogeneous population of multipotent progenitors (MPP; (Pietras et al., 2015)) that further differentiate into two separate lineages, becoming either common…”
• On structural and practical identifiability (2021, background): “It is analyzed increasingly often to judge a model’s predictivity [40, 41, 42, 43, 44].”
• Fundamental limits on dynamic inference from single-cell snapshots (2017, positive): “tens of thousands of cells to generate an ‘atlas’ of cell states in tissues, while also revealing transcriptional gene sets that define these states(2, 3).”
• Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells (2015, methodology): “This could be linked to the recent finding of a developmental switch, where in embryonic development LT-HSCs are the main contributors for most of the blood-cell production in unperturbed hematopoiesis, while in adult life, ST-HSCs assume that role (Busch et al. 2015).”
• Integrated single-cell analysis maps the continuous regulatory landscape of human hematopoietic differentiation (2018, background): “We next turned to LMPPs, a subset previously shown to demonstrate lineage priming toward dendritic (pDC), myeloid (GMP:monocytes), and lymphoid (CLP:B cell) fates in mice (Busch et al., 2015; Naik et al., 2013) and in human (Karamitros et al.”
• Functionally distinct subsets of lineage-biased multipotent progenitors control blood production in normal and regenerative conditions (2015, positive): “However, all these models are interpretations of reconstitution patterns in transplanted mice, which are unlikely to reflect HSC function and lineage specification in native conditions as directly suggested by two recent lineage tracking studies that both showed a limited contribution of HSCs to ong”
• DISTINCT ROUTES OF LINEAGE DEVELOPMENT RESHAPE THE HUMAN BLOOD HIERARCHY ACROSS ONTOGENY (2015, background): “Recent HSC fate-mapping analyses in mice have provocatively shown that progenitors, but not HSCs, are fundamental for ongoing hematopoiesis under homeostatic conditions (27, 28).”