Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity.

By Dimitris P. Xirodimas, M. Saville, J. Bourdon, Ronald T. Hay, David P. Lane. Cell, 2004

605 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/bce929986cf2d8335b5cf0c79484e6cc22913934

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Citations in the corpus

IAPs, RINGs and ubiquitylation (2005, background): “In some situations, MDM2 can modify p53 with a ubiquitin-like molecule called NEDD8 and this modification can destabilize p53 in vitro”
Ubiquitin and ubiquitin-like proteins as multifunctional signals (2005, background): “Among other modifications, the ubiquitylation, sumoylation and neddylation of a group of lysine residues at the C terminus of p53 control the stability and biological activities of this protei”
ROS and p53: a versatile partnership. (2008, background): “The stability and activity of p53 are subject to diverse covalent post-translational modifications such as ubiquitylation [66], phosphorylation [67], acetylation [68], neddylation [69], sumoylation [70], and methylation [71].”
p53 ubiquitination: Mdm2 and beyond. (2006, background): “Regulation of p53 Ubiquitination by Protein Modifications In addition to ubiquitination, phosphorylation and acetylation remain the major posttranslational modifications that occur on p53 and Mdm2 during times of cell stress (Brooks and Gu, 2003), although additional modifications have also been ide”
p53 isoforms can regulate p53 transcriptional activity. (2005, background): “However, p53 protein is subject to multiple post-translational modifications including phosphorylation, acetylation, methylation, ubiquitination, sumoylation, and neddylation (for review, see Oren 2003; Xirodimas et al. 2004).”
Modification of proteins by ubiquitin and ubiquitin-like proteins. (2006, background): “Analogous to the mixed specificity of these ISG15/ubiquitin E3s, the mammalian Mdm2 protein is an E3 ligase that mediates both ubiquitylation and neddylation of the p53 tumor suppressor protein (Xirodimas et al. 2004).”
Post-translational modification of p53 in tumorigenesis (2004, background): “The picture is further complicated by the recent finding that p53 transactivation might also be repressed by neddylation in a process promoted by MDM2 (Ref”