p53 ubiquitination: Mdm2 and beyond.

By C. Brooks, W. Gu. Molecules and Cells, 2006

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Targeting the ubiquitin system in cancer therapy (2009, background): “There is also evidence that other ubiquitin ligases, not inhibited by Nutlins, target p53 for proteasome-dependent degradation (reviewed in ref”
Hydrogen peroxide sensing, signaling and regulation of transcription factors (2014, background): “Like it happens for NRF2, the cellular TP53 levels are mainly regulated by its ubiquitin-mediated proteasomal degradation [190][191].”
Acetylation is indispensable for p53 activation. (2008, background): “p53 is regulated by a variety of posttranslational modifications, including phosphorylation, acetylation, methylation, ubiquitination, sumoylation ,and neddylation (Vousden and Lane, 2007; Brooks and Gu, 2006; Berger, 2007).”
The role of ubiquitination in tumorigenesis and targeted drug discovery (2020, background): “2c).(9,216,217) As mentioned above, deubiquitination is also a key regulatory step in cell metabolism.”
USP10 Regulates p53 Localization and Stability by Deubiquitinating p53 (2010, neutral): “In addition, the cytoplasmic ubiquitin ligase Parc can ubiquitinate p53 and trap p53 in the cytoplasm (Nikolaev et al., 2003).”