IAPs, RINGs and ubiquitylation

By David L. Vaux, J. Silke. Nature reviews. Molecular cell biology, 2005

642 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/8b09e036f301128d5dde7d89520bbb591f66fcc0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. D. Vučić
2. Simone Fulda
3. Ivan Dikic
4. Véronique Baud
5. Daniela Hoeller
6. Sivakumar Vallabhapurapu
7. Sharad Kumar
8. F. Scott

In Oncology

1. M. Karin
2. Véronique Baud
3. D. Vučić
4. Daniela Hoeller
5. Ivan Dikic
6. Sharad Kumar
7. G. Salvesen
8. Simone Fulda

Citations in the corpus

• Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family (2006, background): “Intriguingly, there is evidence that members of the inhibitor of apoptosis protein (IAP) family (Fig 1) are capable of both functions (Riedl & Shi, 2004; Salvesen & Duckett, 2002; Vaux & Silke, 2005a).”
• Targeting the ubiquitin system in cancer therapy (2009, background): “Moreover, c-IAP1, c-IAP2 and X-linked inhibitor of apoptosis (XIAP) trigger autoubiquitylation and self-degradation in response to pro-apoptotic stimul”
• Programmed Cell Death in Animal Development and Disease (2011, neutral): “IAPs are characterized by at least one BIR domain that can directly bind and inhibit caspases (Vaux and Silke, 2005).”
• Targeting IAP proteins for therapeutic intervention in cancer (2012, background): “These RING domain-containing IAP proteins act as E3 ubiquitin ligases — a function that appears to be increasingly important for their role in survival and signalling pathway”
• Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling (2008, background): “In particular, we became interested in the relationships between TRAF2 and TRAF3 and two other RING-containing components of the alternative pathway, cIAP1 and cIAP2, which belong to the IAP (inhibitors of apoptosis) family, characterized by presence of one or more BIR domain”
• Is NF-κB a good target for cancer therapy? Hopes and pitfalls (2009, background): “cIAP1 and cIAP2 belong to the IAP family that has eight members in humans: cIAP1 and cIAP2, XIAP, NAIP (neuronal IAP), ML-IAP (melanoma IAP), Ts-IAP (testis-specific IAP), BRUCE (BIR-containing ubiquitin conjugating enzyme) and survivi”
• Caspase function in programmed cell death (2007, background): “DIAP1 mutant embryos and cells where DIAP1 has been ablated show spontaneous caspase activation and apoptosis.(57) Thus, it seems that in healthy cells DIAP1 is bound to DRONC, preventing its interaction with ARK.”