MicroRNA Functions in Stress Responses

By Anthony Kar Lun Leung, Phillip A. Sharp. Molecules and Cells, 2010

866 citations recorded by the source corpus.

microRNAs (miRNAs) are a class of ~22 nucleotide short non-coding RNAs that play key roles in fundamental cellular processes, including how cells respond to changes in environment or, broadly defined, stresses. Responding to stresses, cells either choose to restore or re-program their gene expression patterns. This decision is partly mediated by miRNA functions, in particular, by modulating the amount of miRNAs, the amount of mRNA targets, or the activity/mode of action of miRNA-protein complexes. In turn, these changes determine the specificity, timing and concentration of gene products expressed upon stresses. Dysregulation of these processes contributes to chronic diseases, including cancers.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6a867065b492dedb3002bdf3c41e301ed482b7c6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Molecular Biology

Citations in the corpus

miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions (2011, background): “miRNAs represent an abundant class of small ~21 nucleotidelong, non-coding RNAs involved in post-transcriptional control of gene expression, which is often related to stress responses.(4) The influence of miRNAs on gene expression is predicted to be widespread, with more than 60% of human protein co”
Cisplatin Resistance: A Cellular Self-Defense Mechanism Resulting from Multiple Epigenetic and Genetic Changes (2012, background): “miRNAs have crucial roles in diverse biological processes, such as phenotypic stabilization, mediating the stress response, apoptosis, proliferation, and maintaining translational thresholds (Bushati and Cohen, 2007; Kosik, 2010; Leung and Sharp, 2010), essentially all areas affected when cells unde”
Resilience in farm animals: biology, management, breeding and implications for animal welfare (2016, background): “Several physiological mediators expressed during activation of innate immune responses such as pro-inflammatory cytokines, micro RNA, heat shock proteins and acute phase proteins can also be upregulated by physical and psychological stressors that have no immunological component (Colditz 2008a; Leun”
Paternal stress exposure alters sperm microRNA content and reprograms offspring HPA stress axis regulation (2013, background): “Of specific interest is the sperm microRNA (miR) content, as miRs are a mode of dynamic epigenetic regulation that rapidly respond to environmental perturbations and likely regulate gene expression postfertilization (Giraldez et al., 2006; Rassoulzadegan et al., 2006; Grandjean et al., 2009; Leung a”
Translational regulation of gene expression during conditions of cell stress. (2010, background): “…posttranscriptional regulation of gene expression during cell stress, which is important in coordinating this response (Babar et al., 2008) (Leung and Sharp, 2010). miRNAs are short ( 22 nt) noncoding RNAs that bind with imperfect complementarity to their target mRNAs, usually at sites…”
MicroRNAs in stress signaling and human disease (2012, neutral): “Leading Edge Review”
The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state (2015, background): “The level of miRNAs can be modulated at the transcription and/or processing level by stressinduced factors like p53 or NF-kB [120].”
miRSystem: An Integrated System for Characterizing Enriched Functions and Pathways of MicroRNA Targets (2012, background): “It has been shown that miRNAs play important roles in many cellular processes such as stress responses [2], hematopoiesis [3], radiation responses [4], and the immune system [5].”